Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
16 Cards in this Set
- Front
- Back
|
Interleukin 1 |
Made by , keratinocytes, macrophages, neutrophils and endothelial cells Attracts neutrophils Increases adhesion of leucocytes to blood vessels (e-selectin and ICAM1) Causes liver to produce complement and acute phase proteins Causes inflammation and fever in response to viruses by macrophages
|
|
|
Interleukin 2 |
Made by TH1 cells Stimulates lymphocyte proliferation and activation Synthesised and secreted by t cells |
|
|
Interleukin 3 |
Stimulates neutrophil/monocyte/eosinophil/basophil production from myeloid progenitor + GMCSF Stimulates mast cell proliferation from myeloid progenitor + stem cell factor c-kit Produced by eosinophils in response to parasites |
|
|
Where is stem cell factor c-kit made? |
By fibroblasts in gut and lung |
|
|
Interleukin 5 |
Stimulates production of eosinophils from a myeloid progenitor Produced by eosinophils in response to parasites Produced by TH2 which stimulates eosinophils
|
|
|
Interleukin 7 |
Stimulates B cells, T cells and natural killer cells by the lymphoid progenitor |
|
|
Interleukin 8 |
Attracts neutrophils and macrophages |
|
|
Interleukin 10 |
Immunosuppressive Produced by regulatory B cells Produced by regulatory T cells - for inhibition of immune response (tolerance) |
|
|
Interleukin 11 |
produces megakaryote from a myeloid progenitor which become platelets |
|
|
Interleukin 12 |
Made my macrophages Stimulates lymphocytes to produce IFgamma Enhanced killing of intracellular pathogens - viruses by macrophages Increase function of NK cells and Cytotoxic t cells |
|
|
Interleukin 13 |
produced by TH2 - stimulates b cells to produce IgE |
|
|
IFN alpha |
Produced by macrophages Interfered with viral replication inside infected cells
|
|
|
IFN beta |
Produced by many cells Interferes with viral replication |
|
|
IFN gamma |
Produced by TH1 cells stimulates macrophages to kill intracellular pathogens Stimulates b cells to produce IgG |
|
|
TNF alpha |
Causes inflammation and fever in response to viruses by macrophages Released by mast cells Attracts neutrophils Made by macrophages Induce E-selectins and ICAM2 for leukocyte adhesion to blood vessels |
|
|
TGF beta |
Produced by regulatory T cells Immunosuppressive Reduces b and t cell proliferation and function Enhances macrophage phagocytosis Deficiency of these is AD |
