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11 Cards in this Set

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  • Back
Describe the conversion of pyruvate to Acetyl CoA.
Pyruvate complexes with TPP. loses CO2; lipoic acid(ox) displace TPP, complexes & is reduced. CoA comes in and displaces Lipoic acid and yields acetyl CoA.
What is step 1 of TCA?
Oxaloacetate + Acetyl CoA +(Citrate Synthase)----> Citrate + CoA-SH
What is the role of acetyl CoA in step 1 of TCA?
As a cofactor, forms LBHB with histidine
What is step 2 Of TCA?
Citrate + (Aconitase)/Fe-S complex -----> Isocitrate
What is step 3 of TCA?
Isocitrate + Isocitrate Dehydrogenase + NAD+ -----> α-ketogluterate + NADH
what is Step 4 of TCA?
α-ketogluterate + lipoic acid + TPP + (α-ketogluterate dehydrogenase) + CoA-SH + NAD+ -----> Succinyl-CoA + NADH + CO2
What is Step 5 of TCA?
Succinyl-CoA + (Succinyl-CoA Synthetase) + GDP ---->Succinate + GTP
What is Step 6 of TCA?
Succinate + (Succinate Dehydrogenase) + FAD+ ----> Fumerate + FADH2
What's Step 7 of TCA?
Fumerate + (Fumerase) + H2O ----> Malate
What's Step 8 of TCA?
Malate + (Malate Dehydrogenase) + NAD+ ----> Oxaloacetate + NADH
What is the net gain of 1 glucose via glycolysis & 2 turns of the TCA?
6 CO2 + 10 NADH + 2 FADH2 + 2 ATP + 2 GTP