Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
11 Cards in this Set
- Front
- Back
|
Describe the conversion of pyruvate to Acetyl CoA.
|
Pyruvate complexes with TPP. loses CO2; lipoic acid(ox) displace TPP, complexes & is reduced. CoA comes in and displaces Lipoic acid and yields acetyl CoA.
|
|
|
What is step 1 of TCA?
|
Oxaloacetate + Acetyl CoA +(Citrate Synthase)----> Citrate + CoA-SH
|
|
|
What is the role of acetyl CoA in step 1 of TCA?
|
As a cofactor, forms LBHB with histidine
|
|
|
What is step 2 Of TCA?
|
Citrate + (Aconitase)/Fe-S complex -----> Isocitrate
|
|
|
What is step 3 of TCA?
|
Isocitrate + Isocitrate Dehydrogenase + NAD+ -----> α-ketogluterate + NADH
|
|
|
what is Step 4 of TCA?
|
α-ketogluterate + lipoic acid + TPP + (α-ketogluterate dehydrogenase) + CoA-SH + NAD+ -----> Succinyl-CoA + NADH + CO2
|
|
|
What is Step 5 of TCA?
|
Succinyl-CoA + (Succinyl-CoA Synthetase) + GDP ---->Succinate + GTP
|
|
|
What is Step 6 of TCA?
|
Succinate + (Succinate Dehydrogenase) + FAD+ ----> Fumerate + FADH2
|
|
|
What's Step 7 of TCA?
|
Fumerate + (Fumerase) + H2O ----> Malate
|
|
|
What's Step 8 of TCA?
|
Malate + (Malate Dehydrogenase) + NAD+ ----> Oxaloacetate + NADH
|
|
|
What is the net gain of 1 glucose via glycolysis & 2 turns of the TCA?
|
6 CO2 + 10 NADH + 2 FADH2 + 2 ATP + 2 GTP
|
