Sulfonamides/trimethoprim

Front 1

sulfanomide

Back 1

bacteriostatic
inhibits PABA, which inhibits dihydrofolic synthesis which ultimately inhibits DNA synthesis.
it is selective to bacteria because we do not synthesize folate, needed for PABA.
used for UTI

Front 2

Trimethoprim

Back 2

inhibits tetrahydrofolate synthesis, which stops DNA synthesis.
also selective to bacteria.
used for UTI
cannot be used during pregnancy/lactation

Front 3

Sulfamethoxazole& Trimethoprim

Back 3

SMZ inhibits PABA and TMP inhibits dihydrofolic acid. they work synergistically.
used for UTI, bronchitis/pneumonia and pneumocystis jirovecii.

Front 4

Resistance

Back 4

-destroy antibiotic
-decrease antibiotic uptake
-increase antibiotic exit
-alter antibiotic target site

Front 5

selection pressure

Back 5

how use of antibiotics promotes bacterial resistance

Front 6

cross resistance

Back 6

if a bacterial strain is resistant to one class of drugs, it is often resistant to all drugs of that class

Front 7

multiple drug resistance

Back 7

if a bacterial strain is resistant to more than one type of antibiotic, it is said to exhibit multiple drug resistance.

Front 8

chromosomal resistance

Back 8

usually gives to 1 or 2 antibiotic resistance
but it is not transferable

Front 9

plasmid resistance

Back 9

usually gives multiple >4 resistance and can be transferred to another bacteria