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17 Cards in this Set
- Front
- Back
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Sulfonamide. Mechanism of action. |
Folic acid synthesis inhibitor. Competitive inhibitor of dihydropteroate synthase. Lack of folic acid therefore Inhibition of DNA synthesis. |
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Sulfonamide spectrum. |
G+ and G- aerobic. Toxoplasma. |
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Sulfonamide Short, medium and long acting names. |
Sulfisoxazole Sulfamethoxazole and sulfadiazine Sulfadoxine |
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Sulfadoxine used for ? |
Malaria. |
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Sulfamethoxazole used for ? |
Urinary tract infections. |
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Adverse effects of sulfonamides |
Allergies reactions : light sensitivity and Stevens Johnson syndrome Hemolytic anemia and hematuria. |
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Trimethoprim. Mechanism of action. Side effects |
Dihydrofolate reductase inhibitor. Also a folic acid synthesis inhibitor. Side effects. Anemia and leukopenia. |
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Combination of trimethoprime with which sulfonamide. And what are it’s uses? |
Trimethoprime-sulfamethoxazole. Used for :- UTI + prostatitis. Respiratory infections. Shigellosis. |
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Combination of drug for malaria |
Pyrimethamine - sulfadoxine |
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Fluroroquinolones ( bactericidal ) Mechanism of action |
Inhibits topoisomerase 2 and 4. |
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Fluoroquinolone spectrum |
G- ;- klebsiella , proteus , H. Influenza and salmonellosis G+ ;- Anthrax Intracellular pathogens like chlamydia |
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Fluoroquinolone Generation 0 name and use. |
Nalidixic acid Active only against G- enteric Bactria. Coli, klebsiella and proteus. |
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Generation 1 |
Norfloxacin Active against G- enteric. |
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Generation 2 |
Ciprofloxacin All uses but most effective G- out of all fluoroquinolone. |
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Generation 3 |
Levofloxacin Better for G+ and intracellular pathogens |
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Generation 4 |
Moxifloxacin Against G+ pneumoniae. |
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Side effects of flurorquinolones |
GI ans CNS side effects. Damages growing cartilages, not used in pregnancy and small children. |
