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12 Cards in this Set
- Front
- Back
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How many carbons does estrane have?
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18 carbons
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How many carbons does androstane have?
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19 carbons
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How many carbons does pregnane have?
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21 carbons
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suffix order of priority
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alcohol (-ol) < ketone (-one) < aldehyde (-al), acid (-oic acid)
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What type of groups do you want on the alpha face of a steroid? (2)
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hydrophobic, small substituents (halogens, methyl). This is to keep the alpha face flat on the receptor
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What types of groups do you want on the beta face of a steroid? (2)
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hydrophilic, h-bonding groups
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The A ring of a steroid
a.) what increases glucocortoid activity? |
a.) unsaturation/ double bond at position 1 and 4, because it lifts the 3 carbonyl to the beta side for increased activity. This results in decreased mineralocorticoid activity
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The A ring of a steroid
a.) what increases mineralocorticoid activity? |
a.) saturation, or no double bond at position 1 and 4. This makes the 3 ketone point down towards the alpha face, making it hydrophilic and increasing mineralo activity (and decreasing glucocorticoid activity).
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What is needed for steroid biosynthesis?
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Cholesterol
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Cholesterol roles (4)
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Cholesterol lost but voted
1.) maintain cell membrane fluidity 2.) composition of lipoproteins 3.) synthesis of bile salts 4.) conversion to vitamin D |
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Cholesterol lost but voted
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Cholesterol roles
Cell membrane fluidity maintenance Lipoprotein composition Bile salt synthesis Vitamin D conversion |
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MOA of steroid hormone
1.) concentration 2.) transport 3.) action 4.) receptor 5.) action 6.) action 7.) action 8.) action 9.) action |
MOA of steroid hormone
1.) steroid hormones are present in small concentrations 2.) they are bound to serum carrier proteins for transport across the blood stream 3.) once they dissociate from serum carrier proteins, they passively diffuse into the cell membrane 4.) there are steroid receptors intracellularly, that are complexed with heat shock proteins. 5.) steroid + receptor = complex as the heat shock protein dissociates off the receptor 6.) steroid receptor complex can dimerize and translocate to the nucleus 7.) interacts with DNA and transcriptional factors 8.) increased production of mRNA 9.) leads to translation and production of proteins that carry out the steroid hormone response |
