Skin Pathology

Front 1

Seborrheic Keratosis

MOA of disease

Back 1

Benign squamous proliferation; common tumor in the elderly

Front 2

Seborrhiec Keratosis

Describe what it looks like

Back 2

Raised, discolored plaques on the extremieties or face

Coin like, waxy, stuck on appearance

Front 3

Back 3

Seborrheic Keratosis

Keratin pseduocyts (The H's)

Front 4

Leser Trelat sign***

Back 4

sudden onset of multiple seborrheic keratoses and suggests underlying carcinoma of the GI tract

Paraneoplastic syndrome

Front 5

Acanthosis Nigricans

MOA of disease

Back 5

Thick epidermis (hyperplasia) with darkening of the skin (velvet like skin)

Front 6

Common locations for Acanthosis Nigricans

Back 6

Axilla and groin

Front 7

What is this?

Back 7

Acanthosis nigricans

Front 8

What is Acanthosis Nigricans associated with?

Back 8

associated with insulin resistance (type II DM)

or malignancy (gastric carcinoma)

Front 9

Basal Cell Carcinoma

MOA of disease

Back 9

Malignant proliferation of the basal cells of the epidermis

Front 10

What is the most common cutanous malignancy?

Back 10

Basal Cell Carcinoma

Front 11

What are the risk factors for basal cell carcinoma?

Back 11

Prolonged exposure to sunlight (UVB light)

Albinism (low melanin which is used to absorb UV light)

Xeroderma pigmentosum

Front 12

What is Xeroderma pigmentosum

Why is it in skin?!

Back 12

AR genetic disease in which the ability to repair damaged DNA is lost (missing enzymes)

predisposes to damage by sunlight

(Known as Children of the Dark --> only come out at night)

Front 13

Basal Cell Carcinoma

Physical appearance?

Back 13

Elevated nodule with central, ulcerated surrounded by dilated vessels (telangiectatic)

"pink pearl like papules"

Front 14

What is the classic location for the basal cell carcinoma to be on?**

Back 14

Upper Lip

Front 15

What is that?

Back 15

Basal cell carcinoma

The basal cells are going crazy (big purple area)

Front 16

What is the treatment and prognosis of basal cell carcinoma?

Back 16

Tx: surgery

Prognosis is very good (metastasis rare)

Front 17

Squamous Cell Carcinoma

MOA behind disease

Back 17

Malignant proliferation of squamous cells characterized by formatoin of keratin pearls

Front 18

Keratin pearl?

Back 18

ALWAYS think of Squamous cell carcinoma (of lungs, skin, esophagous, etc.)

Front 19

Where are squamous cells found? (why the name)

Back 19

They are flat hence the name

They are located in the stratum corneium (and a little below it)

Front 20

Risk factors for Squamous Cell Carcinoma?

Back 20

Sunglight (UVB), albinism, xeroderma pigmentosum

Additional risk factors:
-immunosuppressive therapy
-arsenic exposure
-chronic exposure

Front 21

Physicial appearance of Squamous Cell carcinoma (very similar to basal cell carcinoma)

Back 21

Ulcerated, nodular mass

Front 22

What is the classical location for squamous cell carcinoma to come up on?

Back 22

Lower lip

(note: basal cell carcinoma is upper lip)

Front 23

What is the treatment and prognosis of Squamous Cell Carcinoma?

Back 23

Tx: surgical excision

Prognosis good (metastasis uncommon)

Front 24

Actinic Keratosis

Back 24

hyperkeratotic, scaly plaque

Precursor to squamous cell carcinoma (premalignant)

Front 25

Keratoacanthoma

Back 25

Well differentiated squamous cell carcinoma that develops rapidly and regresses

Front 26

Pt. presents with a picture of a lesion he had 1 week ago. It came about quickly and also went away. What does he have/had?

Back 26

Keratoacnthoma

CUP-shaped filled with stuff

Front 27

What is the Leser Trelat sign?

Back 27

It is the sudden onset of multiple seborrheic keratoses which suggests underlying GI carcinoma

paraneoplastic syndrome

Front 28

Where does Basal cell carcinoma common present?
Where does Squamous cell carcinoma common present?

Back 28

BCC: upper lips

SCC: lower lips