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22 Cards in this Set
- Front
- Back
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What is the antibody for Progressive systemic sclerosis?
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Anti-Scl 70
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What is the triad for Polymyositis?
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proximal muscle weakness
elevated muscle enzymes elevated myoglobin |
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What does CREST stand for?
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calcinosis
Reynaud's esophageal motility sclerodactyly telangiectasia |
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What is the antibody for Hashimoto's thyroiditis?
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anti-microsomal
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What are the 3 major types of amyloid and what diseases do they contribute to?
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1. amyloid light chain = excess light chain; multiple myeloma & Waldenstroms
2. amyloid associated protien = chronic infl, aging 3. amyloid beta = ch21; alzheimer's |
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What is the artus rxn?
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A type III hypersensitivity rxn involving immune complex deposition in the vascular walls, serosa, and glomeruli
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Describe acute transplant rejection
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memory T cells recognize antigen; CD8s destroy graft; Type IV; days to months
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AFP is high in what ds's?
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hepatoma
multiple gestations neural tube defects yolk sac tumor/endodermal sinus ds LOW in Downs syndromes |
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What are the MC metastases?
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bone: MC breast, then lung
brain: MC lung, then breast |
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What are the features of X-linked dominant genetics?
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NO male to male transmission
never skips generations |
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What are the features of autosomal recessive genetics?
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variable
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Give two examples of X-linked dominant ds's
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1. hyperphosphatemic rickets- inherited Vit D resistance, bowed legs
2. incontinentia pigmenti- mini teeth and patchy alopecia |
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If none of the punnett square anaysis work, what do you have to consider?
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1. de novo mutation= new
2. mitochondrial inheritance- only transmitted by females |
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What is phenylketonuria?
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-unable to metabolize phenylalanine break down products & inability to make melanin & NT's NE and D
-results in nephrotoxicity from phenylketones -results in lighter complexion due to dec melanin synthesis |
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What is mucopolysaccharidoses?
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-1 type of lysosomal storage ds
-unable to metabolize GAG's, critical comp of connective tissue -different forms do or don't cause MR and/or corneal clouding -3types: Hurler, Scheie, Hunter(x-link rec) |
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What is sphingolipidoses?
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-1 type lysosomal storage ds
-unable to metab sphinogolipids, molecules typically involved w/ myelin and CNS -6 types: Niemann-Pick, Gaucher's, Krabbe's, Tay-Sachs, Metachromatic dystrophy, Fabry(x-link rec) |
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What is Bernard-Soulier Ds?
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results in excessive bleeding; due to lack of GpIb (needed for platelet adhesion to VWF)
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Flucloxacillin is used for what?
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only for serious infxns
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What drug is used for many types of bacterial infxns, a common drug used for prophylaxis in pts w/ high-risk cardiac conditions who will be undergoing dental procedures that disrupt gingival or oral mucosa?
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Amoxicillin
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What bugs are 2nd generation cephalosporins used for?
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Heamophilus
Enterobacter Neisseria Proteus E coli Klebsiella |
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What is the mneumonic for 2nd gen cephalosporins?
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cefaMANdole
ceFOXitin ceFURoxime cefoTETan |
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What is the mneumonic for 3rd gen cephalosporins used for tough organsims or infxns?
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Tough Assasins
cefTAzidime cefoTAxime defTriAxone |
