Serology Chapters 28, 29, And 30

Front 1

The definition of autoimmunity is a:

Back 1

Decreased tolerance to self antigens.

Front 2

Antibodies demonstrated in pernicious anemia include:

Back 2

Anti intrinsic factor and anti parietal

Front 3

An individual May develop an autoimmune response to:

Back 3

Antigens that do not normally circulate in the blood, altered antigens, loss of immuno regularity function by lymphocyte subset

Front 4

The basic immunologic mechanism responsible for autoimmune disorders is related to:

Back 4

Deposition of circulating immune complexes

Front 5

Self recognition or tolerance is induced by:

Back 5

Elimination of the small clone of immuno competent cells programs react with the antigen, induction of unresponsiveness in immunocompetent cells, induction of unresponsiveness through triggering a suppressor mechanism.

Front 6

Anticardiolipin antibody is associated with:

Back 6

Systemic lupus erythematosus

Front 7

anti-dna antibody is associated with:

Back 7

Systemic lupus erythematosus

Front 8

Antimyelin antibody is associated with:

Back 8

Rheumatoid arthritis

Front 9

the etiology of insulin-dependent diabetes mellitus is:

Back 9

Immune destruction of T lymphocytes in pancreatic islets

Front 10

Pernicious anemia is characterized by:

Back 10

Deficiency of vitamin B12, presence of antiparietal antibodies, presence of I F-blocking antibodies.

Front 11

The most common form of lupus is:

Back 11

Systemic

Front 12

One of the most potent inducers of abnormalities and clinical manifestations of SLE is:

Back 12

Hydralazine and procainamide

Front 13

SLE is more common in

Back 13

Adult women

Front 14

A condition called the what syndrome can be secondary to lupus and may complicate pregnancy.

Back 14

Antiphospholipid

Front 15

The overall incidence of SLE has an increased frequency among

Back 15

African Americans, Native Americans, and Puerto Ricans

Front 16

The most frequent causes of mortality and hospitalized SLE patients with Progressive renal involvement or CNS disease is

Back 16

Infection

Front 17

Serologic assessment of renal disease and systemic lupus erythematosus includes

Back 17

Serum creatinine assay

Front 18

A diffused or homogeneous pattern in antinuclear antibody testing characterizes

Back 18

N-DNA, DS-DNA, histones, ssDNA, DNP, or histones.

Front 19

A speckled pattern in antinuclear antibody testing characterizes

Back 19

Anti-rnp and anti-sm

Front 20

Patients with SLE characteristically manifest

Back 20

Photosensitive facial rash, polyarthritis, and dermatitis

Front 21

Laboratory features of SLE include

Back 21

The presence of ANAs, circulating anticoagulant and immune complexes, and decreased levels of complement

Front 22

A major cellular immunological feature of SLE is

Back 22

Lack of generalized suppressor T cell function, reduction of generalized suppressor T cell function, and hyper production of helper T cells

Front 23

Antibodies directed against what cells including the membrane molecules that mediate their responses are regularly detected in patients with SLE

Back 23

T cells

Front 24

In SLE B lymphocytes exhibit

Back 24

Hyperactivity and uncontrolled production of antibodies

Front 25

Patients with systemic lupus erythematosus exhibit serum antibodies that include

Back 25

Nuclear components, cell surface and cytoplasmic antigens, immunoglobulin IGG

Front 26

What autoimmune disorder is indicated by an increased titer anti Smith antibody

Back 26

Systemic lupus erythematosus

Front 27

The site of deposition of immune complexes in systemic lupus erythematosus is determined by

Back 27

Molecular configuration, immunoglobulin class, and complement fixing ability

Front 28

Many of the clinical manifestations of systemic lupus erythematosus are a consequence of

Back 28

Tissue damage mediated by immune complexes

Front 29

The female to male ratio in patients with rheumatoid arthritis is

Back 29

2.5 to 1

Front 30

Rheumatoid arthritis is characterized by

Back 30

Joint pain and tenderness, presence of rheumatoid factor in the blood, associated with HLA - DR genes

Front 31

Pathogenic organisms hypothesized for rheumatoid arthritis include

Back 31

An ineffective agent or other stimulus binds to receptors on dendritic cells, activated T lymphocytes proliferate and migrate into the joint

Front 32

In rheumatoid arthritis , stimulated macrophages and fibroblasts release cytokines , one that is particularly important is

Back 32

Tnf Alpha

Front 33

The immunoglobulin class is most often associated with rheumatoid factors are

Back 33

IGM and IGG

Front 34

The laboratory serum agglutination assay for rheumatoid Factor

Back 34

Detect IGM rheumatoid factors

Front 35

Which of the following immunoglobulins or molecular component is used in rheumatoid Factor rapid slide assays

Back 35

FC portion of IGG

Front 36

A biologic false positive rheumatoid Factor assay can be manifested by patients with

Back 36

Systemic lupus erythematosus, hepatitis, and syphilis

Front 37

Rheumatoid arthritis can be treated with the what class of drugs

Back 37

Non-steroidal anti-inflammatory, corticosteroid, and disease-modifying antirheumatic

Front 38

The rheumatoid arthritis agglutination test is based on the reaction between patient antibodies in the serum, known as the rheumatoid factor, and an antigen derived from

Back 38

Human gamma globulin IGG

Front 39

Rheumatoid factors are immunoglobulins with specificity for allotypic determinants located on the

Back 39

FC fragment of IGG

Front 40

Rheumatoid factor in a patient's serum may cause a false

Back 40

Positive test for the detection of IGM class antibodies

Front 41

Rheumatoid factors are defined as

Back 41

Auto antibodies with specificity for the FC portion of the immunoglobulin IGG molecule

Front 42

Tissue injury in systemic Rheumatic disorders such as systemic lupus erythematosus is thought to be caused by

Back 42

Deposition of immune complexes

Front 43

In the indirect fluorescent antinuclear antibody test, a homogeneous pattern indicates the presence of antibody to

Back 43

DNA

Front 44

In the indirect fluorescent antinuclear antibody test, a speckled pattern may indicate the presence of antibody to

Back 44

Smith

Front 45

To make a presumptive diagnosis of rheumatoid arthritis which of the following qualitative methods is most sensitive

Back 45

Latex agglutination

Front 46

In the anti double stranded DNA procedure the antigen most commonly utilized is

Back 46

Mouse kidney tissue