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13 Cards in this Set
- Front
- Back
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Androgens are produced by?
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Testis, ovary, adrenal gland
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When would you expect HIGH levels of testosterone?
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Embryonic development, Puberty, and adult life
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What cell is stimulated by LH to synthesize androgens?
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Leydig cells
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what is produced by the adrenal gland
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androstenedione and dehydroepiandrosterone
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How testosterone metabolized?
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LIVER! reduced and conjugated to sulfate and glucuronic acid
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What are some of the odd side effects of testosterone?
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Decreased speramtogenesism , tendon rupture , Decreased metabolism of hypoglycemic drugs (metformin), echinacea increases the risk of hepatotoxity,
Increased bleeding with warfarin |
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When would you use testosterone?
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Hypogonadism, stimulate growth, reverse muscle wasting, breast carcinoma, endometriosis, increase BMD
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what are the anti-androgen drugs?
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Flutamide, Bicalutamide, niluteamide, and spironolactone (amide drugs)
Cyproterone |
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when would you use an anti-androgen drug?
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Hirstuism, prostate cancer, excessive sex drive
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what drugs inhibit 5-A reductase? what does this do?
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Finasteride and dutasteride....it causes a decrease conversion of testosterone. It used in the treatment of benign prostatic hyperplasia
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which anti-fungal is used to inhibit steroid synthesis?
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ketoconazole
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What is the GnRH analog used in prostate cancer?
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Leuprolide
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Natural supplement to treat BPH?
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Saw Palmetto
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