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10 Cards in this Set
- Front
- Back
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Old antifungal that has been widely used topically and in the oral cavity
Commonly used for Candidiasis Increases pores or channels therefore increasing permeability Primarily fungistatic |
Nystatin
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Toxic antifungal that is considered DOC for most serious infections
Administered IV, binds to a sterol to increase permeability through pores and channels Chills and fever, nephrotoxicity, neuropathies, and possibly anaphylaxis are adverse reactions Rifampin, minocycline, and flucytosine enhance the activity of this drug Primarily fungicidal Nephrotoxicity and ototoxicity from drug interactions (aminoglycosides, vancomycin, and loop diuretics) |
Amphotericin B
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2 newer agents that are co-DOC for Aspergillus infections
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Voriconazole and caspofungin
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Antifungal that is seldom used alone
Used to enhance other antifungals’ effect |
Flucytosine
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Topical OTC antifungal that is useful against non-serious vaginal candidiasis, diaper rash, and athlete’s foot
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Miconazole
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Oral/topical agent that is eliminated hepatically
Hepatotoxicity is the major ADR, others include gynecomastia and impotence broad spectrum w/ a MOA similar to Amphotericin drug interaction w/ atorvastatin |
Ketoconazole
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oral/topical agents that concentrate under the fingernails
widely used for the treatment of onychomycosis |
Itraconazole and Terbinafine (DOC for onychomycosis)
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oral/parenteral agent that is used to treat cryptococcal meningitis
also approved and widely used as a single oral dose therapy for vaginal candidiasis |
Fluconazole
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oral agent that concentrates in the skin, hair follicles, and nail beds
fungistatic for dermatophytes used for severe ringworm and onychomycosis |
Griseofulvin
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agent for ophthalmic use
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Natamycin
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