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15 Cards in this Set
- Front
- Back
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How can you tell lymphoma and infection apart?
How were T-cells first identified? What stains one protein brown and the rest not brown? |
border between immature and mature T-cells in lymph nodes
E-rosette phenomenon immunoperoxidase ("mud") |
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What is the criteria for malignancy in lymphoma?
What is usually the first sign of agranulocytosis? Three causes of lymphopenia? |
degree of clonality - homogeneity
multiple mouth ulcers Cushing's, immunodeficiency, stress |
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Immature neutrophils:
Hypersegmented neutrophils: What should you think of when you see "Toxic" granulation and vacuolization? Alder-Reilley bodies: Bits of endoplasmic reticulum in the neutrophils; |
Bands
slowed DNA synthesis sepsis mucopolysaccharidosis Dohle bodies, sepsis |
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"Left shift" refers to what?
"Right shift" refers to what? Causes of high eosinophil count? |
presence of bands in PS
hypersegmented PMN's Hodgkin's, Loeffler's family of diseases, parasitic infections (worms) |
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Typhoid causes which cell type to increase?
Two infectious causes of elevated lymphocytes? Polycythemia vera and chronic granulocytic leukemia have an increase in which cells? |
Monocytes
Pertussis, Coxsackie B2 Basophils |
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Familial Mediterranean Fever is caused by lack of what? which cells does this affect?
How do you treat FMF? Problem in the LYST gene, neutrophil membrane and platelet synthesis: |
lack of pyrin - increases aggregation of neutrophils
colchicine Chediak-Hagashi |
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AD defect in which neutrophil nuclei don't segment fully:
Cat scratch fever, Brucellosis, Plague, tularemia, and yersinia infections cause what type of granuloma? |
Pelger-Huet anomaly
Suppurative granulomas |
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What type of cell do you use to diagnose acute leukemia?
Crystal of primary lysosomes in blasts; Pautier microabscesses are seen in which disease? |
Blasts
Auer rods Mycosis fungiodes (Sezary syndrome) |
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What is the malignant cell in Hodgkin's lymphoma?
"Starry sky" appearance on slides is characteristic of what? Cellular origin? Waldenstrom's macroglobulinemia is which IG? What do you see in the nuclei? |
Reed-Sternberg cell
Burkitt's lymphoma - B-cells IGM - see Dutcher bodies |
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How does a pathologist check for lymphoma via staining?
Two causes of sinus histiocytosis? what are some causes of follicular hyperplasia? |
stains for kappa/lambda chains - monoclonal = malignant
nodes draining a cancer, Whipple's toxoplasmosis, RA, syphilis, AIDS |
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Primary polycythemia is a mutation in what gene?
What "cell" do you see in myeloid metaplasia? What monoclonal protein is caused by a abnormal clone of multiple myeloma? What protein accumulated in the kidney in multiple myeloma? |
Jak2
"teardrop" cell M-protein Bence-Jones protein |
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Characteristic granules in Langerhan's cells in Histiocytosis X:
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Birbeck granules
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Lymphoid tissue - more heterogeneity equals what?
"Ballerina skirt cells", RBC's pushing on edges: |
More benign
Infectious mononucleosis |
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Term for single-cleaved cells in follicular lymphoma:
Auer's rods are only seen in which cells? Nucleated RBC's, lots of bands, eosinophilic granulocytes: Spike in immunoglobulins, "hole in the head": |
buttock cell
Myeloblasts Chronic granulocytic leukemia plasma cell myeloma |
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T-cell mediated autoimmune disease, bone marrow wiped out:
#1 cause of hypersplenism in Egypt? |
aplastic anemia
Schistosomiasis |
