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9 Cards in this Set
- Front
- Back
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Histology changes during pregnancy:
Effect of estrogen, progesterone, prolactin, oxytocin on breast: |
true secretory units sprout from each terminal duct
E - develops big ducts P - develops lobules, ductules (acini) PL - secretory units, milk production O - myoepithelial cells contract, express milk |
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Which part of the breast is usually the most massive?
Usual bug in acute mastitis, breast abscess: solid mass, caused by injury, necrotic cells surrounded by inflammatory infiltrate, calcifications, FB rxn, scarring: What is periductal mastitis? |
upper outer quadrant
S aureus fat necrosis hyperkeratinizing squamous metaplasis going too far down a lactiferous duct - usually smokers |
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enormous overgrowth of the breast stroma and atrophy of lobules, lymphocytes around ducts, ANA's:
Thrombophlebitis of 1+ SQ veins of the breast: Commonest "disease" of the breast: Who usually gets fibrosis? |
inflammatory gigantomastia
Mondor's disease fibrocystic change patients in 30's, usually UOQ's |
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Most common benign breast tumor:
What is a phyllodes tumor? Three major genes that convey genetic risk in breast cancer: |
fibroadenoma
"leaf-like" - bad term for fibroadenoma w/ two epithelial cell layers w/ dense metaplastic, anaplastic stroma; artichoke-like appearance BRCA1, BRCA2, P53 |
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Most commonly-ID'ed lesion on mammogram, usually unilateral, don't usually invade:
How to tell is the cancer is non-invasive: What is comedocarcinoma? |
DCIS (ductal carcinoma in situ)
stain for myoepithelial cells - smooth-muscle myosin heavy chains most common DCIS, solid intraductal proliferation, central necrosis, often calcify, look like blackheads |
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large, pale, mostly-single cancer cells in nipple, looks almost like eczema:
Distinctive proliferation of large tame-looking cells, fills ductules of 1+ lobules, often see signet-ring cells: |
Paget's disease
non-infiltrating (in situ) lobular carcinoma |
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Most breast cancers are what type?
Stellate, hard, chalky-white flecked, yellow (elastin) bands, almost like cutting an unripe pear: Big, bulky, soft tumor, lymphocytes plentiful: clumps of cells in lakes of mucin, gelatinous tumor: |
invasive ductal carcinomas
NST (no special type) ductal carcinoma medullary ductal carcinoma mucinous carcinoma |
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One breast ca that arises from large ducts:
Well formed glands, usually one cell layer thick, best prognosis: Cells arranged in Indian files: molecular signature of lobular carcinoma: |
papillary carcinoma
tubular carcinoma invasive lobular carcinoma loss of e-cadherin expression |
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Most important prognostic indicator:
Stain for cancer cells not easily seen on H&E: Drugs to remember that cause gynecomastia: Explain male breast ca - type, who gets it: |
mets to axillary nodes
cytokeratin 19, mammaglobin digitalis, spironolactone, soy products w/ natural estrogens infiltrating ductal carcinoma, XXY is 20x more common |
