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15 Cards in this Set
- Front
- Back
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Water replacement in response to hypertonicity or hypovolemia is controlled by AVP and thirst
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When have H20 loss in excess of Na loss- kidneys control that under the hormone AVP
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As increase in osmolality is sensed in the brain (osmoreceptors) and when shrink a little bit get a little hypertonic.
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They directly work to stimulate pituitary ADH or AVP release that works on the kidney for reabsorption
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AVP in kidney only controls H20 reabsorption→
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antidiuretic effects → conserve water→ bump up circulation volume and decrease osmolality
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AVP deficiency =
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= Diabetes Insipidus
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Central Diabetes Insipidus:
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o Inability to produce or release ADH from the posterior pituitary due to:
• Head injuries, infections or congenital Distal tubular segments cannot reabsorb water Large volume of dilute urine that can exceed 15L/day Treatment by a synthetic analog of ADH, desmopressin |
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Nephrogenic Diabetes Insipidus:
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• Failure of the distal and collecting tubules and collecting ducts to respond to ADH
Treatment: to correct the underlying renal disorder |
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Aldosterone is a major endocrine regulator of [........]
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Sodium
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Aldosterone: directly controls Na+ handling
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o Secretion controlled by angiotensin 2
o Acts on kidney late distal tubule/collecting duct via steroid (intracellular) receptors to increase sodium reabsorption and potassium excretion o Loss of aldosterone secretion (adrenalectomy in Addison’s disease) • Tremendous loss of Na+ by kidneys • Reduction in plasma sodium concentration • Severe volume depletion and hypotension |
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Role of Natriuretic Peptides in Regulating....
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Sodium and Extracellular Fluid Volume
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Natriuretic Peptides (ANP, BNP) regulate excretion of Na+ during...
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During volume overload
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Atrial muscle cells release...
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ANP in response to overload
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Role of Natriuretic Peptides in Regulating....
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Sodium and Extracellular Fluid Volume
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Natriuretic Peptides (ANP, BNP) regulate excretion of Na+ during...
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During volume overload
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Atrial muscle cells release...
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ANP in response to overload
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