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9 Cards in this Set
- Front
- Back
What are HLA molecules and where are the individual subclasses found? |
Polymorphic surface antigens.
Class I - A, B, Cw - present on most cells
Class II - DR, DP, DQ - present on B cells and activated/injured other cells |
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Name 3 sensitising events for HLA antibodies? |
Pregnancy Blood transfusion Previous transplants |
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How is crossmatch tested? |
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What are options for non-compatible transplants? |
Desensitisation: ABOi |
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What induction drugs are used for immunosuppression? |
IL-2 inhibitors: Basiliximab i.e. Simulect - stops T cells replication and activation of B cell Antithymocyte globin - large reduction circulation T cells via cell lysis |
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What maintenance drugs are used for immunosuppression? |
Steroids: suppressed cell-mediated immunity inhibiting cytokines and TNF Azathioprine: prevents clonal proliferation T and B lymphocytes via blocking purine synthesis, or give MMF - competitive inhibitor IMPDH - inhibit guanosine synthesis - inhibit T and B cell Cyclosporin/Tacrolimus - calcineurin inhibitors - reduced function of T cells Rapamycin - mTOR inhibitor: interferes with signal transduction and lymphocyte clonal proliferation. |
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What are some surgical complications of renal transplantation? |
– Bleeding |
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What are some medical complications of renal transplantation? |
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What are transplant specific complications of renal transplantation? |
– Rejection (cellular, anti-body mediated) |