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9 Cards in this Set
- Front
- Back
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Ace inhibitors action on GFR |
Angiotensin inhibited so there is vasodilation of efferent arteriole, decreasing GFR and also systemic lowering of BP. |
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Prostaglandin E and I's effect on GFR |
Vasodilates afferent arteriole to increase GFR |
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NSAIDs effect on GFR |
Blocks COX enzyme, blocks PG synthesis, so thete is vasoconstriction of afferent arteriole lowering GFR |
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Adenosine is a chemical released from JGA when there is increased NaCl conc in tubule lumen. What does adenosine do in the kidneys? |
Increased GFR is detected via increased NaCl. So adenosine vasoconstricts arterioles, so it lowers GFR and promotes sodium reabsorption. (adenosine antagonists are diuretics) |
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What does adenosine antagonists do? Eg. Caffeine |
Inhibits the adenosine-mediated vasoconstriction of arterioles thereby increasing GFR promoting diuresis. |
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Sympathetic neurones release NA, adrenaline and promote renin release (and angiotensin 2 release) |
Promotes vasoconstriction, increasing peripheral vascular resistance, increasing BP. |
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Give an example of an osmotic diuretic |
Mannitol |
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How does an osmotic diuretic work? |
The substance mannitol enters tubule at glomerulus increasing osmolality. It reduces water and solute reabsorption, thereby promoting urine excretion. |
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How does a carbonic anhydrase inhibitor promote diuresis? |
Inhibits production of bicarbonate and H+ from water and CO2. Results in ??? |
