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8 Cards in this Set
- Front
- Back
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Name two classes of agents used to treat volume or edematous disorders.
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- modulators of neuro-humoral signals: ACE inhibitors
- diuretics or agents increasing Na excretion. |
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Name three common edematous syndromes.
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- CHF
- cirrhosis - nephrotic syndrome |
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What type of edema is this?
- caused by increased vascular permeability. |
exudative edema
- high protein content in ISF |
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What type of edema is this?
- caused by renal Na and volume retention. |
transudative edema
- low protein content in ISF |
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Factors that cause edema.
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- increased hydrostatic pressure: heart failure, venous obstruction.
- hypo-proteinema of malnutrition - increased capillary permeability: inflammation - lymphatic obstruction |
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Mechanism of action of carbonic anhydrase inhibitors.
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- block CAIV(exo-enzyme) and CAII (cytoplasmic) -> HCO3- not absorbed -> pulling Na+ and water down the lumen
- more Cl- absorbed: maintain charge neutrality - H+ retention -> metabolic acidosis |
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How do carbonic anhydrase inhibitors cause metabolic acidosis?
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- block CAIV(exo-enzyme) and CAII (cytoplasmic) -> HCO3- not absorbed
- more Cl- absorbed: maintain charge neutrality - H+ retention -> metabolic acidosis |
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Uses of carbonic anhydrase inhibitors.
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- glaucoma: ciliated epithelium secretes NaCl into acqeous humor requiring CA associated with Cl-/HCO3- exchange.
- altitude sickness: Cl-/HCO3- exchange in choroid plexus in the brain. - gout: uric acid more soluble at alkaline pH. |
