Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
40 Cards in this Set
- Front
- Back
|
FGF 2
|
angiogenesis
angioplast in embryo recruits macrophages, fibroblasts, endothelilal cells to damage (wound repair) |
|
|
FGF and VEGF
|
needed for angiogenesis (VEGF more indirect via IFN g and IL 1)
|
|
|
Protein C
|
degrades factor Va and VIIIa
|
|
|
medium sized cells with basophilic cytoplasm and proliferation fraction (Ki-67) of >99%
|
EBV; Burkitt's lymphoma
high proliferation index with medium sized lymphocytes |
|
|
FGF 2
|
angiogenesis
angioplast in embryo recruits macrophages, fibroblasts, endothelilal cells to damage (wound repair) |
|
|
FGF and VEGF
|
needed for angiogenesis (VEGF more indirect via IFN g and IL 1)
|
|
|
RAS
|
proto onco gene
makes cell more sensitive to mitogen |
|
|
Protein C
|
degrades factor Va and VIIIa
|
|
|
Erb B2 gene
|
tyrosine kinase activity realted to EGF = breast and ovarian cancer
|
|
|
Li Fraumeni syndrome
|
AD
p53 mutation tumors <45 yrs |
|
|
medium sized cells with basophilic cytoplasm and proliferation fraction (Ki-67) of >99%
|
EBV; Burkitt's lymphoma
high proliferation index with medium sized lymphocytes |
|
|
Rb
|
TS
retinoblastoma and osteosarcoma |
|
|
RAS
|
proto onco gene
makes cell more sensitive to mitogen |
|
|
NF2
|
TS
NF type 2 bilateral acoustic neuromas bilateral hearing loss, vertigo and tinnitus |
|
|
Erb B2 gene
|
tyrosine kinase activity realted to EGF = breast and ovarian cancer
|
|
|
Li Fraumeni syndrome
|
AD
p53 mutation tumors <45 yrs |
|
|
schistocytes
|
decreased haptoglobin since hemoglobin levels are much greater
increased LDH and bilirubin |
|
|
Rb
|
TS
retinoblastoma and osteosarcoma |
|
|
NF2
|
TS
NF type 2 bilateral acoustic neuromas bilateral hearing loss, vertigo and tinnitus |
|
|
schistocytes
|
decreased haptoglobin since hemoglobin levels are much greater
increased LDH and bilirubin |
|
|
dysplastic vs carcinoma
|
Reversibility of changes, dysplastic cells never break basement membrane
|
|
|
Hb AS
|
Hb S = 35-40%, protected from sickle cell crisis, aplastic crisis
SS = >80% sodium metabisulfite = sickling |
|
|
hemosiderin
|
golden yellow, hemoglobin derived marker of iron accumulation in macrophages
|
|
|
Intrinsic Apoptosis
|
bcl 2 proteins; balance between pro and anti apoptotic
MPT (mito perm transition) --> release of cytochrome C --> caspase |
|
|
vWF deficiency
|
easy bleeding from mucosal sites
AD w/ variable incomplete penetrance low ferritin from Iron deficient anemia |
|
|
c-myc
|
transcription activator for cell proliferation differentiation and apoptosis
|
|
|
cyclin D
|
mantle cell t11 14
g1 to s phase promoter |
|
|
AML (APL)
|
hemorrhagic signs, bone marrow with immature myeloid cells
|
|
|
prolonged bleeding time, PTT, and uncle with some blood disorder
|
vWF (expecially if it's female)
|
|
|
Follicular lymphoma
|
most indolent
marked by remissions and recurrences MC presentation: painless LN enalargement or abdominal discomfort + mass |
|
|
hairy cell leukemia
|
splenomegaly and pancytopenia
positive TRAP |
|
|
HUS from shigella and EHEC
|
microangiopathic hemolytic anemia
look for bloody diarrhea! thrombocytopenia due to endothelial injury |
|
|
CCl4
|
P450 system to CCl3 --> free radical injury to hepatocytes + fatty liver change
|
|
|
iron deficiency
|
hypochromic microcytic anemia
|
|
|
collagen amino acids
|
gly x y
|
|
|
post translational changes to collagen
|
lysyl hydroxylation
glycosylation of lysine residues cleavage of N and C terminal propeptide (defective in Ehlers Danlos) lysyl oxidase cross linking |
|
|
reduced end plate potential
|
MG (less receptors and opening of nicotinic cation channels)
|
|
|
bone matrix formation problem
|
OI
|
|
|
colchicine SE
|
nausa, diarrhea and abdominal pain
|
|
|
sublimation vs displacement
|
sublimation is taking emotion and applying it to something more acceptable (gym when angry)
displacement is emotions to inappropriate target (breaking vase when angry) |
