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13 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Prazole |
PPI
Forms disulfide bond with custom residues within alpha subunit of HK atpase |
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PPI metabolism
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Liver p450
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Reduce dose in hepatic disease
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PPI SE
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Headache, GI issues, hip fractures, reduce effect of antiplatelet agents such as clopidogrel
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H2RA
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Compete with histamine for binding to H2 receptors on parietal cells
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Tidine
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H2RA
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H2RA metabolism
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Kidneys
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Reduce in kidney disease
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Cimetidine side effect
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Inhibit liver CYP
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Misoprostol
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Synthetic analog of Prostaglandin PGE1
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Note: prostaglandins actually decrease acid secretion by binding to PGEP3 receptors on parietal cells
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Misoprostol SE
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Diarrhea and cramping!!!
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Sucralfate
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Sulfated polysaccharide
Cross links to make a viscous polymer that adheres to epithelia and ulcers . Stimulates prostaglandin synthesis. Binds bile acids. |
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Antacids examples
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Sodium bicarbonate
Caco3 - gas Mg OH - diarrhea/laxative effect Al OH -constipation |
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chronic GERD is risk for
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BE and esophageal Adenocarcinoma
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Metoclopramide
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D2 receptor blocker
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