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6 Cards in this Set
- Front
- Back
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Leflunomide
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Dihydroorotate dehydrogenase (increase CPS, decrease orotic acid)
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Mycophenolate and ribavirin
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IMP dehydrogenase (increase IMP, decrease GMP)
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Hydroxyurea
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ribonucleotide reductase (increase UDP, decrease dUDP)
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6-MP and azithioprine (prodrug)
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de novo purine synthesis (increase PRPP, decrease IMP)
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5-FU
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thymidylate synthase (decrease dTMP, increase in dUMP)
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MTX (humans), TMP (bacteria), pyrimethamine (protozoa)
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DHFR inhibitor (decrease dTMP)
inhibits from DHF > THF |
