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3 Cards in this Set
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- Back
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Amphetamine related: Amphetamine,methamphetamine, methylenedioxymethamphetamine, methylphenidate |
MOA:Taken by uptake 1--by VMAT--gets into the synaptic vesicle Effects: Increased in motor activity, euphoria & excitement, sympathetic stimulation(peripheral effect) Good oral absorption Medical use: mainly by methylphenidate; ADHD,by increasing dopamine. Narcolepsy, by increasing excitement SE:anorexia,psychotic behaviour, sympathomimmetic effects Methylenedioxymethamphetamine(ecstasy as party drug):inhibits 5HT uptake+release of 5HT SE:acute hyperthermia,water intake, heart failure |
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Methylxanthine derivatives: Theopylline, caffeine |
Origin:coffee,tea,or cola plant MOA: CNS--antagonism as A2 purine rec. Peripheral--inhibition of phosphodieterase;;B agonist like effects Effects:CNS stimulation in terms of concentration and reduction of fatigue. Doesnt cause euphoria & less locomotor stimulation. Diuresis,stimulation of cardiac muscle, relaxation of smooth muscle(bronchial muscle). Good oral absorption. Only theophylline is used medically |
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Cocaine |
MOA: Inhibits uptake 1---sympatomimmetic effects and CNS effects Effects: euphoria,increased motor activity, magnification of pleasure, enhanced mental capability. given as nasal injection and i.v infusion No medical use, but it is an ester type local anesthetic |
