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60 Cards in this Set
- Front
- Back
What is neuronal plasticity?
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parts of the brain remodel to compensate in response to changes in environment or received inputs
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what is declarative memory?
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memory for general and autobiographical facts
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what is nondeclarative memory?
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memory for learned behaviors both explicit and implicit. AKA procedural memory
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What kind of metabolic activity is thought to occur in neurons to facilitate long term learning?
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Synthesis of proteins and RNA in neurons that synapse during short term learning
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The limbic system: collects imputs from?
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the hypothalamus (and therefore collects visceral signals from sensory cortex and brainstem), prefrontal cortex and inferior temportal association cortex
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The limbic system: mediates?
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emotional and instinctual responses
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The limbic system: important structures include?
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Amygdala, hippocampus
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the amygdala is involved in?
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fear, anxiety
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the hippocampus is involved in?
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learning, memory
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T/F the basal ganglia is deep gray matter?
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TRUE
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important structures of the basal ganglia include?
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caudate, putamen, thalamus, neurotransmitter systems, and RAS
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the caudate becomes severly in atrophies in what disease?
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huntington's
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the putamen and caudate have a high concentration of what kind of receptors which are the target of antipsychotic drugs, causing abnormal involuntary movements?
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D2 receptors
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the thalamus is involved in?
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sensation and pain
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what are the dopamine pathways?
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nigrostriatal, mesocortical, mesolimbic, tuberoinfundibular
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which dopamine pathway connects the substantia nigra to caudate and putamen?
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nigrostratal
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which dopamine pathway connects the VTA to the prefrontal cortex?
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mesocortical
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which dopamine pathway connects the VTA to amygdala and hippocampus?
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mesolimbic
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which dopamine pathway connects arcuate nucleous of the hypothalamus to the pituitary?
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tuberoinfundibular
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anti-psychotics block D1 and D2 that are rich in this pathway.
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what the nigrostriatal pathway?
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this dopamine pathway mediates cognition and is responsible for negativism seen schizo via D1, seratonin (5-HT) receptors.
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whatis the mesocortical pathway?
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excess dopamin here causes hallucinations seen in schizo?
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what is the mesolimbic pathway?
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blockade of dopamine via antipsychotics here causes elevated prolactin?
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what is the tuberoinfundibular pathway
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this association region of the brain recieves input from the neocortex, limbic regions, hypothalamic regions, brainstem, and most of the rest of the brain via the thalamus.
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what is the prefrontal cortex?
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the prefrontal cortex is responsible for what behavior?
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executive function
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exmaples of executive funtion?
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abstract thought, creative problem solving, temporal sequencing of behavior
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what are examples of tests that assess the intactness of the prefrontal cortex?
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wisconsin card sorting, Go/No-Go tasks, Trails tests
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with regards to prefrontal intactness, peeps with schizoprenia may be thought of as having?
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hypofrontality
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with regards to prefrontal intactness, people with OCD may be considered as having?
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hyperfrontality
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dopamine pathways in general originate from either the ____ or the ____?
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ventral tegmental area, arcuate nucleus
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the norepinephrine system arises from ____ and has projections to_____?
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locus ceruleus, the entire brain
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the serotonin (5-HT) system arises in?
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the raphe nucleus
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TBI most commonly affects the?
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frontal lobes
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another term for long term memory is?
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consolidated memory
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aphasia is a disorder of?
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language, NOT speech
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important structures associated with language are typically localized to?
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the left hemisphere in most people
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broca's area is where and controls what?
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posterior frontal cortex, speech production and fluency
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the wernicke's area is where and does what?
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posterior temportal lobe, permits understanding or interpretation of language
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lesions in this area cause expressive aphasia
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what is broca's area?
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lesions in this area cause receptive aphasia.
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what is wernicke's area?
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2 diagnostic criteria for TBI?
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an injury occurred and there was alteration of consciousness
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this excitatory amino acid neurotransmitter is thought to causes neurodegeneration through excessive excitation.
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what is glutamate?
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anxiolytic drugs are ____ agonists and and increase _____ tone in the CNS.
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GABA, inhibitory
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90% of the population is right handed and left hemisphere dominant for?
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language and praxis
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right hemisphere is dominant for?
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complex perceptual processing such as facial recognition
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lesions of the dominant parietal lobe can result in?
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language abnormalities, tactile agnosia and apraxia
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lesions of the non-dominant parietal lobe can result in?
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anosognosia, constructional dyspraxia, and contralateral neglect
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lesions of the dominant temporal lobe can result in?
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anomia and anterograde verbal amnesia
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lesions of the nondominant temporal lobe can result in?
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anomia for facial expressions and anterograde visiospatial amnesia
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bilateral lesions of the temporal lobes can cause?
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korsakoff;s amnesia and kluver-bucy syndrome
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What lesion? Tactile agnosia
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L parietal
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What lesion? Language Abnormality
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L parietal
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What lesion? Contralateral neglect
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R parietal
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What lesion? Disinhibition and impulsivity?
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Frontal lobe
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What lesion? Anomia, anterograde amnesia?
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L temporal
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What lesion? Anomina for facial expression, (visuospatial) anterograde amnesia?
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R temporal
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What part of the limbic does fear and anxiety?
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amygdala
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What part of the limbic does learning and memory?
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hippocampus
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T/F attentional defecits are NOT localizable?
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TRUE;
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Ach neurons from the nucleus basalis of meynert project to the ________ for memory, and the _______ for attention?
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Hippocampus; Cingulate gyrus
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