Psych Meds

Front 1

CNS stimulants
3

Back 1

methylphenidate, dextroamphetamine, mixed amphetamine salts

Front 2

CNS stimulants (MOA and use)

Back 2

Increase catecholamines at synaptic cleft, especially NE & dopamine.

Hint 2

ADHD, narcolepsy, appetite control

Front 3

Typical Antipsychotics (5)
↑ Potency
↓ Potency

Back 3

haloperidol, trifluoperazine, fluphenazine,
thioridazine, chlorpromazine

Front 4

Typical Antipsychotics MOA

Back 4

Block dopamine D2 receptors → ↑(cAMP)₁

Front 5

Typical Antipsychotics uses

Back 5

Schizophrenia positive symptoms, psychosis, acute mania, Tourette's
-used to decrease agitation in acute delirium/dementia

Front 6

high potency Antipsychotics (3) & what are what makes them high potency?

Back 6

Haloperidol, trifluoperazine, fluphenazine

Front 7

Extra pyramidal symptoms

Back 7

= CNS SE's = Acute dystonia, akinesia, akathisia, tardive dyskinesia

Front 8

low potency antipsychotics & what makes them low potency?

Back 8

Thioridazine, chlorpromazine

Front 9

Anticholinergic SE's & from blocking what receptor?

Back 9

histamine = sedation & eat more → ↑ weight

Front 10

Neuroleptic malignant syndrome: what is it & what do you treat it with?

Back 10

High fever, encephalopathy, vitals unstable, elevated enzymes, muscle rigidity

Front 11

Corneal deposits

Back 11

chlorpromazine

Front 12

retinal deposits

Back 12

thioridazine

Front 13

tardive dyskinesia

Back 13

stereotypic oral-facial movements due to long term antipsychotic use, irreversible

Front 14

atypical antipsychotics

Back 14

olanzapine, clozapine, quetiapine, risperidone, aripiprazole, ziprasidone (geodon)

Front 15

atypical antipsychotics MOA

Back 15

Block 5HT2, dopamine, alpha, H1 receptors

Front 16

atypical antipsychotics uses

Back 16

schizophrenia positive AND negative Sx

Front 17

atypical antipsychotic SE's

Back 17

Same as typicals but FEWER!

Front 18

what atypical antipsychotic causes agranulocytosis?

Back 18

clozapine

Front 19

what 2 atypical antipsychotics cause weight gain & ∴ ↑ risk for DM?

Back 19

olanzapine and clozapine

Front 20

Lithium (MOA, use)

Back 20

Not sure.

Front 21

Lithium (toxicity)

Back 21

tremor, sedation, edema, heart block, polyuria (ADH antagonism causes nephrogenic DI = ↓ urine osmolarity), HYPOTHYROIDISM, teratogenesis (ebstein anomaly of heart), narrow therapeutic window.

Front 22

What's special about it?

Back 22

Stimulates 5HT₁a receptors.

Front 23

Tricyclic antidepressants

Back 23

imipramine, amitriptyline, desipramine, nortriptyline, clomiprmaine, doxepin, amoxapine

Front 24

tricyclic antidepressants (MOA, use)

Back 24

Block reuptake of NE and serotonin.

Front 25

tricyclic toxicity's

Back 25

Three C's of tricyclics: Convulsions, Coma, Cardiotoxicity (arrythmias)

Front 26

Which TCA would you use in elderly & why?

Back 26

Nortripyline

Front 27

SSRI

Back 27

fluoxetine, paroxetine, sertraline, citalopram, fluvoxamine

Front 28

SSRI (use and moa)

Back 28

serotonin specific reuptake inhibitors. Use: depression, OCD, bulimia, social phobia, any anxiety disorder

Front 29

SSRI toxicity

Back 29

Serotonin syndrome (with any drug that increases serotonin) GI distress, sexual dysfunction.

Front 30

What is Serotonin syndrome?

Back 30

hyperthermia, muscle rigidity, cardiovascular collapse, flushing, diarrhea, seizures.

Front 31

Which drugs assoc c Seratonin Syndrome?

Back 31

SSRI, SNRI, MAOI's, St. John's Wort, Kava Sibutramine, Tryptophan, Cocaine, amphetamines

Front 32

SNRI

Back 32

venlafaxine, duloxetine, desvenlafaxine, nefazodone, milnacipran, sibutramine→(only use for wt. loss)

Front 33

SNRI (use and MOA)

Back 33

inhibit serotonin & NE reuptake.

Front 34

SNRI SE's

Back 34

↑ BP, stimulant effect, sedation, nausea

Front 35

MOA inhibitors

Back 35

phenelzine, tranylcypromine, isocarboxazid, selegiline (selective)

Front 36

MOA inhibitors (use and MOA)

Back 36

nonselective inhibition of Monoamine oxidase → increase levels of amine NT's = NE, 5HT, & DA

Front 37

MOA inhibitors (SE)

Back 37

Hypertensive crisis c tyramine (in aged cheese/wine, beef..anything aged) ingestion & c β-agonists.

Front 38

NDRI

Back 38

Buproprion

Front 39

Bupropion everything you know:

Back 39

used for moking cessation.

Front 40

Who would be the perfect pt for this drug?

Back 40

alpha 2 antagonist → increase release of NE & serotonin) and potent 5H2 and 5HT3 receptor antagonist. Is a tetracyclic

Front 41

maprotiline: everything you know:

Back 41

blocks NE reuptake

Front 42

Trazodone everything you know:

Back 42

inhibits serotonin reuptake, is a teteracyclic

Front 43

tetracyclics: (2)

Back 43

trazadone & mirtazapine

Front 44

Amantadine

Back 44

a Parkinson's drug can be given to tx SE's of antipsychotics (choreiform movements/etc)

Front 45

what is the best drug to use in a Parkinson's pt's who get psychotic and why?

Back 45

Quetiapine = atypical antipsychotic

Front 46

CNS stimulants

Back 46

methylphenidate, dextroamphetamine, mixed amphetamine salts

Hint 46

CNS stimulants (MOA and use)

Front 47

Use: ADHD, narcolepsy, appetite control

Back 47

Typical Antipsychotics

Hint 47

haloperidol, trifluoperazine, fluphenazine, thioridazine, chlorpromazine

Front 48

use: Schizophrenia, psychosis, acute mania, Tourette's

Back 48

Typical Antipsychotics uses

Hint 48

Schizophrenia positive symptoms psychosis

Front 49

used to decrease agitation in acute delirium/dementia

Back 49

high potency Antipsychotics (3) & what are what makes them high potency?

Hint 49

Haloperidol, trifluoperazine, fluphenazine

Front 50

More extrapyramidal symptoms than low potency

Back 50

Extra pyramidal symptoms

Hint 50

= CNS SE's = Acute dystonia, akinesia, akathisia, tardive dyskinesia

Front 51

Have more anticholinergic side effects vs high potency (which have extrapyramidal SE's)

Back 51

Anticholinergic SE's & from blocking what receptor?

Hint 51

histamine = sedation & eat more → ↑ weight

Front 52

muscarinic = dry mouth, constipation,

Back 52

Neuroleptic malignant syndrome: what is it & what do you treat it with?

Hint 52

High fever, encephalopathy, vitals unstable, elevated enzymes, muscle rigidity

Front 53

Treat with dantrolene or bromocriptine = dopamine agonist

Back 53

Corneal deposits

Hint 53

chlorpromazine

Front 54

Use these in catatonic/disorganize schizophrenics vs. typicals

Back 54

atypical antipsychotic SE's

Hint 54

Same as typicals but FEWER!

Front 55

excreted in proximal convoluted tubule c Na⁺

Back 55

Lithium (toxicity)

Hint 55

tremor, sedation, edema, heart block, polyuria (ADH antagonism causes nephrogenic DI = ↓ urine osmolarity), HYPOTHYROIDISM, teratogenesis (ebstein anomaly of heart), narrow therapeutic window.

Front 56

Does not cause sedation, addiction or tolerance or interact with alcohol (unlike Benzo's/barbiturates)

Back 56

Tricyclic antidepressants

Hint 56

imipramine, amitriptyline, desipramine, nortriptyline, clomiprmaine, doxepin, amoxapine

Front 57

fibromyalgia = imipramine & amitryptyline b/c make you sleepy = which helps their Sx's

Back 57

tricyclic toxicity's

Hint 57

Three C's of tricyclics: Convulsions, Coma, Cardiotoxicity (arrythmias)

Front 58

Also: respiratory depression, hyperperexia, & anticholinergic SE's = hypotension, sedation, dizziness

Back 58

Which TCA would you use in elderly & why?

Hint 58

Nortripyline

Front 59

has fewer anticholinergic SE's

Back 59

SSRI

Hint 59

fluoxetine, paroxetine, sertraline, citalopram, fluvoxamine

Front 60

Treatment: cool body down FIRST!, then benzodiazepines, THEN if you want cyproheptadine (5HT2 receptor antagonist)

Back 60

Which drugs assoc c Seratonin Syndrome?

Hint 60

SSRI, SNRI, MAOI's, St. John's Wort, Kava Sibutramine, Tryptophan, Cocaine, amphetamines

Front 61

sibutramine = weight loss med

Back 61

SNRI SE's

Hint 61

↑ BP, stimulant effect, sedation, nausea

Front 62

WASH OUT PERIOD = need to be off MAOI's for 2 weeks before starting SSRI's, SNRI's, Buproprion

Back 62

MOA inhibitors (SE)

Hint 62

Hypertensive crisis c tyramine (in aged cheese/wine, beef..anything aged) ingestion & c β-agonists.

Front 63

CNS stimulation, DO NOT USE c SSRIs or meperidine to prevent serotonin syndrome

Back 63

NDRI

Hint 63

Buproprion

Front 64

USE IN: LOL who can't sleep & won't eat & is depressed.

Back 64

maprotiline: everything you know:

Hint 64

blocks NE reuptake

Front 65

Tox: sedation, orthostatic hypotension

Back 65

Trazodone everything you know:

Hint 65

inhibits serotonin reuptake, is a teteracyclic

Front 66

trazaBONE

Back 66

tetracyclics: (2)

Hint 66

trazadone & mirtazapine

Front 67

CNS stimulants

Back 67

methylphenidate, dextroamphetamine, mixed amphetamine salts
CNS stimulants (MOA and use)

Hint 67

Increase catecholamines at synaptic cleft, especially NE & dopamine.

Front 68

Use: ADHD, narcolepsy, appetite control
Typical Antipsychotics

Back 68

haloperidol, trifluoperazine, fluphenazine, thioridazine, chlorpromazine
Typical Antipsychotics MOA

Hint 68

Block dopamine D2 receptors → ↑(cAMP)₁

Front 69

More extrapyramidal symptoms than low potency
Extra pyramidal symptoms

Back 69

= CNS SE's = Acute dystonia, akinesia, akathisia, tardive dyskinesia
low potency antipsychotics & what makes them low potency?

Hint 69

Thioridazine, chlorpromazine

Front 70

Treat with dantrolene or bromocriptine = dopamine agonist
Corneal deposits

Back 70

chlorpromazine
retinal deposits

Hint 70

thioridazine
tardive dyskinesia

Front 71

Use these in catatonic/disorganize schizophrenics vs. typicals
atypical antipsychotic SE's

Back 71

Same as typicals but FEWER!
what atypical antipsychotic causes agranulocytosis?

Hint 71

clozapine
what 2 atypical antipsychotics cause weight gain & ∴ ↑ risk for DM?

Front 72

Does not cause sedation, addiction or tolerance or interact with alcohol (unlike Benzo's/barbiturates)
Tricyclic antidepressants

Back 72

imipramine, amitriptyline, desipramine, nortriptyline, clomiprmaine, doxepin, amoxapine
tricyclic antidepressants (MOA, use)

Hint 72

Block reuptake of NE and serotonin.

Front 73

has fewer anticholinergic SE's
SSRI

Back 73

fluoxetine, paroxetine, sertraline, citalopram, fluvoxamine
SSRI (use and moa)

Hint 73

serotonin specific reuptake inhibitors. Use: depression, OCD, bulimia, social phobia, any anxiety disorder
SSRI toxicity

Front 74

Treatment: cool body down FIRST!, then benzodiazepines, THEN if you want cyproheptadine (5HT2 receptor antagonist)
Which drugs assoc c Seratonin Syndrome?

Back 74

SSRI, SNRI, MAOI's, St. John's Wort, Kava Sibutramine, Tryptophan, Cocaine, amphetamines
SNRI

Hint 74

venlafaxine, duloxetine, desvenlafaxine, nefazodone, milnacipran, sibutramine→(only use for wt. loss)
SNRI (use and MOA)

Front 75

sibutramine = weight loss med
SNRI SE's

Back 75

↑ BP, stimulant effect, sedation, nausea
MOA inhibitors

Hint 75

phenelzine, tranylcypromine, isocarboxazid, selegiline (selective)
MOA inhibitors (use and MOA)

Front 76

CNS stimulation, DO NOT USE c SSRIs or meperidine to prevent serotonin syndrome
NDRI

Back 76

Buproprion
Bupropion everything you know:

Hint 76

used for moking cessation.

Front 77

trazaBONE
tetracyclics: (2)

Back 77

trazadone & mirtazapine
Amantadine

Hint 77

a Parkinson's drug can be given to tx SE's of antipsychotics (choreiform movements/etc)
what is the best drug to use in a Parkinson's pt's who get psychotic and why?

Front 78

CNS stimulants

Back 78

methylphenidate, dextroamphetamine, mixed amphetamine salts;CNS stimulants (MOA and use)

Front 79

Use: ADHD, narcolepsy, appetite control;Typical Antipsychotics

Back 79

haloperidol, trifluoperazine, fluphenazine, thioridazine, chlorpromazine;Typical Antipsychotics MOA

Front 80

use: Schizophrenia, psychosis, acute mania, Tourette's;Typical Antipsychotics uses

Back 80

Schizophrenia positive symptoms psychosis

Front 81

used to decrease agitation in acute delirium/dementia;high potency Antipsychotics (3) & what are what makes them high potency?

Back 81

Haloperidol, trifluoperazine, fluphenazine

Front 82

More extrapyramidal symptoms than low potency;Extra pyramidal symptoms

Back 82

= CNS SE's = Acute dystonia, akinesia, akathisia, tardive dyskinesia;low potency antipsychotics & what makes them low potency?

Front 83

Have more anticholinergic side effects vs high potency (which have extrapyramidal SE's);Anticholinergic SE's & from blocking what receptor?

Back 83

histamine = sedation & eat more → ↑ weight

Front 84

muscarinic = dry mouth, constipation,;Neuroleptic malignant syndrome: what is it & what do you treat it with?

Back 84

High fever, encephalopathy, vitals unstable, elevated enzymes, muscle rigidity

Front 85

Treat with dantrolene or bromocriptine = dopamine agonist;Corneal deposits

Back 85

chlorpromazine;retinal deposits

Front 86

Use these in catatonic/disorganize schizophrenics vs. typicals;atypical antipsychotic SE's

Back 86

Same as typicals but FEWER!;what atypical antipsychotic causes agranulocytosis?

Front 87

excreted in proximal convoluted tubule c Na⁺;Lithium (toxicity)

Back 87

tremor, sedation, edema, heart block, polyuria (ADH antagonism causes nephrogenic DI = ↓ urine osmolarity), HYPOTHYROIDISM, teratogenesis (ebstein anomaly of heart), narrow therapeutic window.;Buspirone MOA & use:

Front 88

What's special about it?

Back 88

Stimulates 5HT₁a receptors.

Front 89

Does not cause sedation, addiction or tolerance or interact with alcohol (unlike Benzo's/barbiturates);Tricyclic antidepressants

Back 89

imipramine, amitriptyline, desipramine, nortriptyline, clomiprmaine, doxepin, amoxapine;tricyclic antidepressants (MOA, use)

Front 90

fibromyalgia = imipramine & amitryptyline b/c make you sleepy = which helps their Sx's;tricyclic toxicity's

Back 90

Three C's of tricyclics: Convulsions, Coma, Cardiotoxicity (arrythmias)

Front 91

Also: respiratory depression, hyperperexia, & anticholinergic SE's = hypotension, sedation, dizziness;Which TCA would you use in elderly & why?

Back 91

Nortripyline

Front 92

has fewer anticholinergic SE's;SSRI

Back 92

fluoxetine, paroxetine, sertraline, citalopram, fluvoxamine;SSRI (use and moa)

Front 93

Treatment: cool body down FIRST!, then benzodiazepines, THEN if you want cyproheptadine (5HT2 receptor antagonist);Which drugs assoc c Seratonin Syndrome?

Back 93

SSRI, SNRI, MAOI's, St. John's Wort, Kava Sibutramine, Tryptophan, Cocaine, amphetamines;SNRI

Front 94

sibutramine = weight loss med;SNRI SE's

Back 94

↑ BP, stimulant effect, sedation, nausea;MOA inhibitors

Front 95

WASH OUT PERIOD = need to be off MAOI's for 2 weeks before starting SSRI's, SNRI's, Buproprion;MOA inhibitors (SE)

Back 95

Hypertensive crisis c tyramine (in aged cheese/wine, beef..anything aged) ingestion & c β-agonists.

Front 96

CNS stimulation, DO NOT USE c SSRIs or meperidine to prevent serotonin syndrome;NDRI

Back 96

Buproprion;Bupropion everything you know:

Front 97

Who would be the perfect pt for this drug?

Back 97

alpha 2 antagonist → increase release of NE & serotonin) and potent 5H2 and 5HT3 receptor antagonist. Is a tetracyclic

Front 98

USE IN: LOL who can't sleep & won't eat & is depressed.;maprotiline: everything you know:

Back 98

blocks NE reuptake

Front 99

Tox: sedation, orthostatic hypotension;Trazodone everything you know:

Back 99

inhibits serotonin reuptake, is a teteracyclic

Front 100

trazaBONE;tetracyclics: (2)

Back 100

trazadone & mirtazapine;Amantadine