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69 Cards in this Set

  • Front
  • Back

Minimum duration of symptoms needed to diagnose depression

Two wks

Core symptoms of depressive episode according to ICD-10

Low mood


Anhedonia( lack of pleasure)


Fatiguability/ lack of energy

How many DSM criteria should be there to diagnose depression

5/9

What is recurrent depressive dx

Repeated episodes of mild/moderate/severe Depression without manic episodes with complete recovery in btwn episodes

Bipolar depression in comparison to unipolar depression.



1. Duration


2. Response to treatment


3. Previous hx of manic or hypomanic episodes

1. Long duration


2. Poor

Rate of major depression in community samples

2-5%

Life time rate of major depression

10-20%

Major depression M:F ratio

1:2

Mean age of onset

27 yrs

Duration of a depressive episode

1-6 months

Percentage getting chronic lasting depression more than two years

10-20%

Percentage experiencing more than one episode

85%

Minor symptoms of depression- first three

Reduced concentration and attention


Reduced self esteem and self confidence


Ideas of guilt amd unworthiness

Minor symptoms of depression- last 4

Bleak and pessimistic view about future


Ideas or acts of self harm and suicide


Disturbed sleep


Diminished appetite.

How to differentiate grief from depression

Grief- no low self esteem

Pseudodementia vs dementia

Pseudodementia- more acute in onset, other symptoms of depression, respond to antidepressants

Common somatic symptoms of depression

Body aches


Back pain


Burning sensation


Fatigue

Differentiating depression vs schizophrenia,



1. Mood-


2. Delusions


3. Thought related-


1. Low mood prominent( depression), psychotic symptoms prominent( schizophrenia)



2. Mood incongruent delusions( schizophrenia), mood congruent delusions- nihilism, guilt( depression)



3. Thought insertion, withdrawal, broadcasting, passivity( schizophrenia)



Depression vs schizophrenia



4. PPHx



5. FMHx

4. Depressive or manic episodes( depression), psychotic episodes(schizophrenia)



5. Depressive or bipolar illness( depression), schizophrenia( schizophrenia)

To determine the severity of illness, number of symptoms as well as_______is important

Degree of functional imapirment

Mild depression- diagnostic criteria

2+2


None should be present to a severe degree

Functional level of mild depression

Usually distressed by symptoms,


Some diffculty in continuing ordinary work


But do not cease to function completely.

Diagnostic criteria for moderate depression

2+3/4


Several symptoms- at a marked degree.

Functional level of moderate depression

Considerable difficulty in continuing social, work and domestic activity

Causes of depression- three main categories

Bio


Psycho


Social

Biological causes of depression

Genetic


Physical


Endocrine dx


Medications


Substance use

Psychological causes of depression

Personality


Relationship issues.

Social causes of depression

Financial


Marital


Workplace


Other stressors



Biological causes of depression- family hx

Fmhx of depression, bipo dx, suicide

Biological causes of depression. Pmhx

Any chronic illness


( malignancy, mi, stroke, epilepsy, parkinson dx, renal and liver dx, chronic pain, DM, SLE)

Biological causes of depression- medications

Analgesics usage



Antibiotics


Antihypertensives



chemo


Steroid


Immunosupressants

Biological causes of depression- substance use hx

Alcohol


Cannabis


Heroine


(/quantity. Frequency and duration of use)

Biological causes of depression- physical examination

Features of physical illness and endocrine dx

Biological causes of depression-lab ix

Relevant ix according to hx


Urine for drug screen

Diagnostic criteria for severe depression

3+4


Some symptoms- to a severe degree

Can diagnosis of severe depression made if duration less than 2 wks

Yes. If symptoms are very severe nd of rapid onset

Functional level of severe depression

Unable to continue activity

Delusions of gult inoves ideas of

Sin


Poverty


Imminent disasters


Responsibility for bad things

Examples of delusions of nihilism

Internal organs are destroyed.


Dead


Lost all possessions

Examples of auditory hallucinations in depression


defamatoryAccusatory

Examples of olfactory hallucinations in depression

Rotten flesh etc.

Examples of long term relationship problems leading to depression-



Relationship with mom- role in depression.?



Social stressors leading to depression-



Positive events that can lead to depression-

Risks to self-



Risk to others-


Indicators of high suicidal risk


1. Thoughts- 4



2. Past hx



3. Lack of-2



4. Availability-1



5. Habits-1



Wherw do you get info to assess risk-2

How to assess the risk of self neglect



1. Hx


2. Examination-

Psychosocial Aetiology of depression.



Current stressors-



Personality assessment-


1. Coping strategies-


2. Relationship-


3. Personality-

4 endocrine dx well lnown to cause depression

How family members and workmates give social support

Details about previous episodes



1. Frequency-


2. Details of individual episodes-


3. Treatment-


4. Response to treatment-


5. Interepisode period-


6. Precipitated factors-

Goals of treatment- first 4



Goals of treatment- second 4



Indications for admission-



Outpatient mx- two things done at each clinic review.

Education of pt and family



1. What is depression-



2. Rx options-



3. Time taken to respond-



4. SE



5. How long to continue-



How to respond to their cultural views?

Steps to provide supportive environment-



In ward-



Outpatient-

Minimizing harms-



1. In a psych ward-



2. If sent to a non psych ward-

1. How to minimize harm at home-



2. If trying to harm others better to-



3. Which groups are vulnerable to self neglect-



4._______ preferred in self nglect risk

1. Psychotic depression- combination of_________ better than antidepressants.



2. BP depression- drug classes



3. Efficacy of TCA vs SSRI?


(Then why SSRI preferred?)

Factors affecting medication choice?



2 most effective SSRI s?



Fluoxetine more effective in______



SSRIs should be used cautiously in children and adolescents bcz________



TCA- effective in severe depression, but not the first choice why?



____________more effective than ssri for severe depression.

SNRI- CVS se?



Why MAOI rarely used?



TCA contraindications-



TCA best avoided in bcz of-

Rare fatal se of antidepressants in elderly-



TCA overdose se-



TCA in pt with suicidal risk?



SNRI safety?



Cheapest antidepressant class



Cheapest SSRI?

Previous Rx hx in choice of antidepressants-



Role of pt preferance in choice?



Time to appear se?



Time taken to give response?



SSRI starting dose( concept)



Why lower doses of SSRI for elderly?



Why not to stop abruptly?



Withdrawal symptoms of SSRI?



How TCA started?



Why slow dose titration with TCA?



If poor response after two wks?



When to change drugs?



Which symptoms improve earlier than others?

Structure to analyse info during assessment- 2

Risk assessment


Identifying social support


Reasons for relapse


Details of previous episodes.

SSRIs- why to carefully use when there are physical comorbidities

Bcz enzyme inhibition


Poor elimination in hepatic failure

SSRIs- the most potent cyt p450 inhibitors

Fluoxetine


Paroxetine

SSRI- least potent cytp450 inhibitors

Citalopram


Sertraline

Steps-to ensure safe antidepressant use when there are physical comorbidities

Laise with physician


Start lower doses and slowly titrate

How to minimize risk of relapse

After first episode- rx at least 6 months


Recurrent episodes- long term Rx



If recurrent- Lithium, CBT- reduce risk of relapse

Indications for ECT

Psychotic features


Stupor


Risk of self harm, self neglect


Postpartum depression


Poor response to meds

No. Of ECT cycles/ wk

2-3

Total number of ECT cycles/ per cycle

6-12