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36 Cards in this Set

  • Front
  • Back
Normal function of Alpha1 receptors
vasoconstriction
ejaculation
contraction of bladder neck and prostate
Normal function of Beta 1 receptors
Heart (increases rate, force of contraction, velocity of conduction in AV node)
Kidney (renin release)
Normal function of Beta 2 receptors
Bronchial dilation
Relaxation of uterine muscle
Vasodilation
Glycogenolysis
Normal function of Dopamine Receptors
Dilates renal blood vessels
Normal function of Muscarinic receptors
Slows heart rate
Increases gastric secretions
Emptying bladder and bowel
Focuses eye for NEAR vision
Constricting pupil
Contracting bronchial smooth muscle
Erection in men
Increases saliva
Normal function of Nicotinic receptors
Paralysis for anethesia (SUCCINYLCHOLINE)
Sleep
Anxiety
Processing pain
Cognitive function
Chemical warfare
What is the MOA of Bethanechol
selective agonist at muscarinic cholinergic receptor
What are the therapeutic uses of Bethanechol
Urinary retention
Gastrointestinal uses
What is the MOA of Atropine
muscarinic antagonist (receptor blockade)
What is the MOA of Tolterodine
muscarinic antagonist (used for Overactive bladder)
What is the MOA of Ipratopium
muscarinic antagonist
What is the MOA of Ipratopium
muscarinic antagonist
What is the MOA of Succinylcholine
It is a depolarizing neuromuscular blocker that works on the nicotinic receptors preventing acetylcholine to activate it through depolarization
What is the therapeutic use of Succinylcholine
muscle relaxation during intubation (ultra short-acting peak at 1 min fades in 4-10)
Adverse effects of Succinylcholine
Malignant hyperthermia
Postoperative muscle pain
Hyperkalemia
Prolonged apnea
What is the MOA of Albuterol
Beta 2 activation (direct receptor binding)
What is the MOA of Dopamine
Activation of peripheral dopamine receptors (dilates vasculature of kidney allowing increased blood flow in kidney failure)
What is the MOA of Epinephrine
Activates Alpha 1&2 and Beta 1&2 (lots of therapeutic and adverse effects
What is the therapeutic uses of Epinephrine
-EpiPen
-Elevates blood pressure
-AV block reverse
-Dilation of bronchioles in asthma
What are the adverse effects of Epinephrine and Norepinephrine
Angina pectoris
Hypertensive crisis
Necrosis following extravasation
Dysrhythmias
What is the MOA of Norepinephrine
Activates Alpha 1&2 and Beta 1
What is Norepinephrine used for
hypotensive state
cardiac arrest
What adverse effect does Epinephrine have that norepinephrine doesn't
Hyperglycemia (because E works on B2 and NE doesn't)
What is Dopamine's receptor specificity
LOW DOSE : dopamine receptors
MODERATE DOSE: dopamine and beta 1 receptors
VERY HIGH DOSE: Alpha1, Beta 1 and dopamine receptors
What is the MOA of Alfuzosin
adrenergic antagonist that is an alpha receptor blocker
What is the MOA of Phenoxybenzamine
adrenergic antagonist that is an alpha receptor blocker
What is the MOA of Propranolol
individual beta receptor blocker on both beta 1 and beta 2
What is the MOA of Metoprolol
individual beta receptor blocker on both beta 1 and beta 2
What are the adverse effects of beta-adrenergic antagonists II
-bradycardia
-AV heart block
-Heart failure
-rebound cardiac excitation
-Inhibition of glycogenolysis
-bronchoconstriction
What are contraindication of beta-adrenergic antagonists II
severe allergy
diabetes
cardiac, respiratory & psychiatric disorders
What is the MOA of Clonidine
selective activation of alpha 2 receptors in the CNS thus decreasing sympathetic outflow to blood vessels and the heart
What are the therapeutic uses of Clonidine
Hypertension
Severe pain
What are the adverse effects of Clonidine
-Don't use in pregnancy
-Rebound hypertension
-Drowsiness
-dry mouth (xerostomia)
-Others (constipation, impotence, gynecomastia)
What is the MOA of Methyldopa
causes alpha 2 activation by being taken up into brainstem and being converted into an alpha 2 agonist
What are the therapeutic uses of Methyldopa
Hypertension
What are the adverse effects of Methyldopa
hemolytic anemia
hepatotoxicity
others (dry mouth, sexual dysfunction, orthostatic hypotension)