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13 Cards in this Set
- Front
- Back
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Biopharmaceutics definition |
Study of how physiochemical properties of APIs, dosage forms and routes of administration affect rate and extent of API action |
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Pharmacodynamics |
What API does to the body |
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Pharmacokinetics |
What the body does to the API |
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ADME |
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From tablet to desired effect through GI tract |
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How is dissolution rate different from solubility? What factors affect rate? |
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What steps do suspension and solution skip? |
Suspension-disintegration Solution-disintergration and dissolution |
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What's bioavailability? What does F equal for IV injectables? |
Fraction of an administered dose that reaches bloodstream (F). F would equal 1 or 100%. |
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if api doesn't dissolve fast. If dosage form no release api. |
API doesn't dissolve quick enough, simply passes through GIT. No api can be absorbed |
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Poor bioavailability consequences |
Need lots of api Make dosage form large and inconvenient Inefficient, expensive Patient to patient variation in absorption will have a bigger effect than with APIs that are well absorbed |
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Label |
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What is half-life? what to do for short half life? |
Time taken for concentration in body to fall to half its value. Controlled release formulation to extend useful therapeutic periods for APIs with short half lives. |
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Role of pharmaceutics |
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