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9 Cards in this Set
- Front
- Back
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blood composition |
70 ml/kg bw, plasma 55%, cells 45% |
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plasma components |
- water 90% - plasma proteins 6-8% - electrolytes eg Na+, Cl- 1% - nutrients eg glucose,AA - hormones eg cortisol, thyroxine - wastes eg urea - bld gas eg CO2, O2 |
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major classes of plasma proteins |
albumin 60% - maintain osmotic p. globulin 36% - alpha,beta(transport lipid), gamma(type of a/body) fibrinogen 4% - bld coag |
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albumin |
-single peptide chain -585 aa with 17 disulfide bonds - synthesized in liver, produced 12g perday - half live 20 days |
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albumin function no. 1/2 |
transport : - metal eg calcium, copper - ffa : alb binds with ffa released by adipose to transfer to other tissue - bilirubin : alb binds with bili & transport to liver to be absorbed by hepatocytes - bile acid : alb carries bile acid to liver - hormones eg thyroid & steroid |
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albumin function no.2/2 |
maintain osmotic pressure -protein in bld plasma excrete colloid osmotic pressure that will pull water into circulatory sys bcos large p.protein unable to cross capillary walls |
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hypoalbuminemia |
- low plasma alb - in malnutrition, nephrotic synd & liver cirrhosis |
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hyperalbuminemia |
- plasma alb increased in acute dehydration - no clinical significance |
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edema |
decrease synthesis of alb esp in liver disease & starvation causing... |
