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100 Cards in this Set

  • Front
  • Back
Major functions of the skin
- Homeostasis
- Heaviest single organ in body, 16% of body weight.
- Provides boundaries for body fluid, protects underlying tissues from microorganisms, harmful substances and radiation.
- Modulates body temp, synthesizes vitamin D
Layers of skin
- epidermis
- dermis
- subcutaneous tissue

Hair, nails, and sebaceous and sweat glands are appendages of skin.
Vellus hair
Short, fine, less pigmentation
Terminal hair
Coarser, pigmented (scalp/eyebrows)
Nails
Protect distal ends of fingers/toes
Sebaceous glands
Contained in the dermis, present all surfaces except palms/soles, produce a fatty substance secreted onto skin surface through hair follicles.
Sweat glands
Contained in the dermis, includes eccrine and apocrine glands.
Eccrine glands
Widely distributed, open directly onto skin surface, help control body temp
Apocrine glands
Found in axilla and groin, stimulated by emotional stress.
Detection of suspicious moles
- patient education
- skin cancers are most common cancers in US
- most prevalent on hands, neck, and head
- patients initially detect nearly 1/2 of melanomas
- 30% of melanomas are missed by providers
Basal cell carcinoma
- comprises 80% of skin cancers
- shiny and translucent
- grow slowly and rarely metastasize
Squamous cell carcinoma
- comprise 16% of skin cancers
- crusted, scaly, and ulcerated, can metastasize
Melanoma
- comprises 4% of skin cancers
- rapidly increasing in frequency, spread rapidly
HARRM Risk factors for melanoma
- History of previous melanoma
- Age over 50
- Regular dermatologist absent
- Rapid mole changing
- Male gender
Additional risk factors for melanoma
≥50 common moles
≥1-4 atypical or unusual moles (especially if dysplastic)
Red or light hair
Actinic lentigines, macular brown or tan spots (usually on sun exposed areas)
Heavy sun exposure (especially severe childhood sunburns)
Light eye or skin color (especially freckles/burns easily)
Family history of melanoma
ABCDE Screening moles
A - asymmetry
B - border irregularity
C - color variation (blue or black)
D - diameter ≥6 mm or different from other moles, especially changing, itching, or bleeding
E - elevation, enlargement, evolution
Macule
- flat, non-palpable, circumscribed, less than 1cm
- brown, red, purple, white, tan color
- freckles, moles, Café-Au-Lait spot)
Patch
- flat non to minimally palpable, irregular shape, a macule that is >1cm
- Vitiligo, port-wine marks, Café-Au-Lait spot)
Papule
- elevated, palpable, firm, circumscribed, <1 cm
- brown, red, pink, tan, bluish-red color
Plaque
- elevated, flat topped, firm, rough, a superficial papule >1cm
- psoriasis, seborrheic and actinic keratosis)
Wheel
- elevated, irregular-shaped area of cutaneous edema, solid, transient, changing, variable diameter
- pink with lighter colored center
- urticaria, insect bite
Nodule
- elevated, firm, circumscribed, palpable, deeper in dermis, 1-2 cm diameter
- erythema nodosum, lipoma
Tumor
elevated, solid, may or may not be demarcated, >2cm. (neoplasms)
Vesicle
- elevated, circumscribed, superficial, filled with serous fluid, < 1cm
- blister, varicella
Bulla
- vesicle >1cm in size
- blister, pemphigus vulgaris
Pustule
- elevated, superficial, similar to vesicle but filled with purulent fluid (pus)
- acne, impetigo
Cysts
- elevated circumscribed, palpable, encapsulated, filled with liquid or semisolid
- sebaceous cyst
Scale
- heaped up keratinized cells, flaky exfoliation, irregular; variable thickness, moisture, and size
- silver, white, tan
- psoriasis, exfoliative dermatitis)
Crust
- dried serum, blood, or purulent exudate; slightly raised, varies in size
- brown, red, black, tan, or straw
- scab, abrasion, eczema
Lichenification
- rough, thickened epidermis, accentuated skin markings, often of flexor aspects of extremities
- chronic dermatitis
Keloid
- irregularly shaped, elevated progressively enlarging scar
- grows beyond wound boundaries, caused by excessive collagen formation.
Excoriation
- loss of epidermis, linear or hollowed-out crusted area
- abrasion, scratch
Fissure
- linear crack or break form epidermis to dermis; small, deep, red
- athletes foot, cheilosis
Ulcer
- loss of epidermis and dermis; concave; red, white, or reddish blue
- decubitus ulcer, statis ulcer
Erosion
- loss of all or part of epidermis, depressed, moist; follows rupture of vesicle or bulla
- larger than fissure
- varicella
Inspect and palpate skin
Note characteristics of:
Color
Moisture
Temperature
Texture
Mobility and turgor
Lesions
When inspecting color, look for:
- increased pigmentation, loss of pigmentation
- redness, pallor (decreased redness of skin found in anemia and decreased blood flow), cyanosis, and yellowing

Red color (normal) of oxyhemoglobin best assessed at fingertips, lips, and mucous membranes.

Abnormal could be sign of anemia, hypoxia/cyanosis, ischemia

In dark-skinned people, palms and soles
For central cyanosis, look in lips, oral mucosa, and tongue.
Vitiligo
- depigmented macules, usually face, hands, feet extensor surfaces
- hereditary disorder due to lack of melanin.
Cafe-au-lait spot
slightly but uniformly pigmented macule or patch with mildly irregular boarders
Cyanosis
- somewhat bluish color of the skin, lips, oral mucosa, or nails.
Cause: due to poor oxygenation of tissues
Either centrally form lack of oxygenated blood or peripherally from lack of circulation to tissues or venous return.
Jaundice
yellowing of the skin, most easily seen in sclera.

Causes: liver disease, hemolysis of red blood cells
Skin moisture
Dryness, sweating, and oiliness
Dryness: hypothyroidism, renal disease
Oiliness: acne
Sweating: hyperhidrosis
Skin temperature
Use back of fingertips and hand
Identify warmth or coolness of skin
Increased warmth: infection (cellulitis), increased vascularity, fever
Cold: ischemic to tissues, Raynaud’s syndrome, hypothyroidism, shock
Skin texture
Roughness or smoothness
Roughness: renal disease, hypothyroidism, ichthyosis
Smoothness: CREST syndrome
Skin mobility and tugor
Lift fold of skin
Note ease with which it lifts up (mobility) and speed with which it returns to place (turgor)
Mobility decreased – edematous states
Mobility increased – age, collagen-elastin diseases
Turgor decreased – dehydration
Turgor increased – edematous states
Skin lesions
Note characteristics
Anatomic location and distribution
Many skin diseases have a typical distribution
Psoriasis – knees, elbows, extensor surfaces
Candida infections – intertriginous areas (groin, armpits, areas that are always moist)
Eczema – flexor surfaces
Pityriasis rosea – back and chest in “Christmas tree pattern”
Skin lesion patterns and shapes
Many lesions occur is a typical pattern and shapes
Shapes: annular, serpiginous (worm like), oval, round
Patterns: dermatomal (shingles), clustered, linear
Skin lesion types
Type of lesion (macules, plaque, nodule/papule just depending on size, vesicles)
Skin lesion color
Many skin lesions have the same predictable coloring
Café-Au-Lait spot (brown, tan)
Psoriasis (silvery and red base)
Flat, non-palpable lesions with changes in skin color
Macule—Small flat spot, up to 1.0 cm
Patch—Flat spot, 1.0 cm or larger
Palpable elevations: solid masses
Papule
Plaque
Nodule
Cyst
Wheal - urticaria
Palpable elevations with fluid-filled cavities
Vesicle, bulla, pustule
Burrow (scabies)
Slightly raised tunnel in the epidermis
Commonly found on the finger webs and on the sides of the fingers
Looks like a short, linear or curved gray line and may end in a tiny vesicle
Look for the burrow of the mite that causes scabies
Secondary skin lesions
Scale, Crust, Lichenification, Scars, Keloids, Erosion, Excoriation, Fissure, Ulcer
Vascular and purpura lesions
Spider angioma, spider vein, hemangioma, petechia (smaller), purpura (larger), ecchymosis
Janeway lesion
Small nontender hemorrhagic macular to nodular lesions present on the palms and soles of patients with infectious endocarditis. (septic emboli)
Osler nodes
Similar to Janeway however they are erythematous tender and slightly raised, more common on the fingers and toes
Squamous cell carcinoma
Location: Appear on sun exposed areas, typically fair skinned and older than 60 yo.
Pattern: none
Type: papule to tumor, with scaling/crusting or ulceration
Color: reddened
Actinic keratosis
Superficial, flattened papules covered by a dry scale; round or irregular; tan, brown, or grayish. Appears on sun exposed skin, and can develop into SCC
Basal cell carcinoma
Mostly fair skinned, >40 yo, slow growing seldom metastasizes
Location: Face
Pattern: none
Type: nodule, occasionally depressed center
Color: pearly to gray, with telangiectasia
Seborrheic keratosis
Common, benign, “stuck on lesion”
Location: typically trunk and face
Pattern: symmetric to none
Types: papule to plaque, texture: greasy/velvety
Color: brown, tan, yellow, gray
Melanoma
Remember ABCD
Benign nevus
Common mole, may arise over time, usually unchanged in ABCD’s.
Round, defined boarders, uniform color, flat or raised
Corn and callus
Toughened areas of skin due to repeated friction exposure
Location: typical feet and hands
Pattern: none
Types: scale
Color: skin colored to yellowed
Lentigo (sun spot)
Benign pigmented spot
Location: sun exposed areas, dorsal hands, arms, face
Pattern: irregular
Type: macule with defined boarders
Color: tan to brown
Wart
Viral infection of the skin (HPV)
Location: any (typically hands, feet, genitalia)
Pattern: grouped to single
Type: papule to domed to tumor
Color: flesh colored with cauliflower appearance
Dermatofibroma
Benign slow growing firm lesion
Location: any
Pattern: none
Type: roundish nodule, dimples or involutes with squeezing
Color: usually brown or tan
Rosacea
Chronic erythema of nose and face with acne-like lesions and telangiectasia. Onset 30-60 yo.
Psoriasis
Location: mainly extensor surfaces
Pattern: irregular
Type: plaque, papule
Color: silvery on a erythematous base
Auspitz sign – Pulling off the scale causes bleeding
Pityriasis rosea
Benign self limiting rash
Location: trunk
Pattern: “christmas tree”, annular
Type: maculopapular, scaly
Color: reddish, tan
Herald Patch
Eczema
Location: mainly flexor surfaces
Pattern: area
Type: dry, scaling, fissured, lichenification, maculopapular
Color: skin colored to slightly red
Tinea versicolor
Infection of the skin due to fungus (Tinea)
Location: usually trunk
Pattern: diffuse
Type: macular, scaly
Color: tan
Molluscum contagiosum
Due to a viral infection of the skin
Location: typically extremities to any
Pattern: may form in autoinoculation patterns
Type: dome shaped vesicle with central umblication
Color: flesh colored or translucent
Folliculitis
Infection of the hair follicle typically by Staph or Strep
Location: any
Pattern: grouped to none
Type: pustules
Color: red
Herpes zoster (shingles)
Reactivation of Varicella Zoster causing painful rash
Location: typically trunk or face
Pattern: dermatomal
Type: vesicles
Color: clear vesicles on erythematous base
Varicella zoster (chicken pox)
Infection of Varicella
Location: begins trunk and spreads peripherally
Pattern: crops with different stages of healing
Type: vesicle
Color: clear vesicle on red base “dew on a rose petal”
Acne
Location: face, chest, back
Pattern: variable
Type: pustules, closed and open comedones, papules, cysts
Color: red
Inspect and palpate hair
Note quantity, distribution and texture.
Alopecia areata
Clearly demarcated round or oval patches of hair loss, usually affecting young adults and children.
No visible scaling or inflammation, no broken shafts
Trichotillomania
Hair loss from pulling, plucking, or twisting hair.
Hair shafts are broken and of varying lengths.
More common in children, often in settings of family or psychosocial stress.
Tinea capitis (ringworm)
Round scaling patches of alopecia. Hairs are broken off close to the surface of the scalp. Mimics seborrheic dermatitis.
Inspect and palpate nails
Note color and shape, lesions. Longitudinal bands of pigment may be a normal finding in people with darker skin.
Paronychia
A superficial infection of the proximal and lateral nail folds adjacent to the nail plate.
The nail folds are often red, swollen, and tender.
Most common infection of the hand, usually from Staphylococcus aureus or Streptococcus species.
Arises from local trauma due to nail biting, manicuring or frequent hand immersion in water.
Clubbing of the fingers
Bulbous swelling of the soft tissue at the nail base, with loss of the normal angle between the nail and the proximal nail fold.
The angle increases to 180° or more, and the nail bed feels spongy or floating.
Seen in congenital heart disease, interstitial lung disease and lung cancer, inflammatory bowel diseases, and malignancies
Onychomycosis
Nail is thickened and discolored: white, black, yellow or green.
Nail can become brittle, with pieces breaking off or coming away from the toe or finger completely.
If left untreated, the skin can become inflamed and painful underneath and around the nail.
There is usually no pain or other bodily symptoms
People experience significant psychosocial problems due to the appearance of the nail
White spots (leukonychia)
Trauma to the nails is commonly followed by non-uniform white spots that grow slowly out with the nail.
Spots in the pattern illustrated are typical of overly vigorous and repeated manicuring.
The curves in this example resemble the curve of the cuticle and proximal nail fold.
Transverse linear depressions (Beau's lines)
Bilateral transverse depressions of the nail plates resulting from temporary disruption of proximal nail growth from systemic illness.
Timing of the illness may be estimated by measuring the distance from the line to the nail bed
nails grow approximately 1 mm every 6 to 10 days
Seen in severe illness, trauma, and cold exposure if Raynaud's disease is present.
Mee's lines
Transverse white bands that cross the nail parallel to lunula.
Seen with arsenic poisoning, heart failure, Hodgkin’s disease, chemotherapy, carbon monoxide poisoning, and leprosy
Pitting
Punctate depressions of the nail plate caused by defective layering of the superficial nail plate by the proximal nail matrix. Associated with psoriasis
Subungual hemorrhage
A collection of blood beneath the nail due to trauma. If there is not a broken bone underneath it, you can simply remove it. If there is a fracture of the nail plate, and you drain this out, you’ve just opened it up for infection! BAD.
AIDS and skin conditions
Hairy leukoplakia, Kaposi's sarcoma, herpes simplex virus (HSV), human papillomavirus (HPV), cytomegalovirus (CMV), molluscum contagiosum, candidiasis, squamous cell carcinoma, psoriasis (often severe), seborrheic dermatitis (often severe)
Diabetes and skin conditions
Acanthosis nigricans, candidiasis, neuropathic ulcers, peripheral vascular disease
Dyslipidemia and skin conditions
Xanthomas (tendon, eruptive, and tuberous), xanthelasma (may occur in healthy people)
Hypothyroidism and skin conditions
Dry, rough, and pale skin; coarse and brittle hair; myxedema; skin cool to touch; thin and brittle nails
Hyperthyroidism and skin conditions
Warm, moist, soft, and velvety skin; thin and fine hair; vitiligo; pretibial myxedema (in Graves' disease); hyperpigmentation (local or generalized)
Chronic renal disease and skin conditions
Pallor, pruritus, hyperpigmentation, uremic frost
Liver disease and skin conditions
Jaundice, spider angiomas and other telangiectasias, palmar erythema
Peripheral vascular disease and skin conditions
Dry, scaly, shiny atrophic skin; dystrophic, brittle toenails; cool skin; hairless shins; ulcers; pallor; cyanosis; gangrene
Pregnancy and skin conditions
Melasma, increased pigmentation of areolae, linea nigra, palmar erythema, varicose veins, striae, spider angiomas, hirsutism
Rocky mountain spotted fever and skin conditions
Erythematous rash that begins on wrists and ankles, then spreads to palms and soles; becomes more purpuric as it generalizes