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14 Cards in this Set

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Drugs administered by an Enteral route must be placed?
within the lumen of the gastrointestinal system including the mouth.
Most drugs administered Enterally are designed to be absorbed?
across the wall of the gastrointestinal tract, to enter the systemic circulation and to be delivered to target cells and tissues elsewhere in the body.
A few drugs are administered Enterally actually target what cells and tissues?
Cells and tissues within the gastrointestinal tract; these drugs include antacids and laxatives.
drugs targeting bacterial infections within the gastrointestinal tract will usually be administered this way.
Enterally
Usually, a oral drug is swallowed so that it can enter?
the stomach and small intestine where it is absorbed across the wall of the gastrointestinal tract.
Drugs administered orally must be administered in a form which can easily be?
swallowed, which is not destroyed by the acid conditions of the stomach or by the enzymes within the stomach or small intestine, and which can be absorbed across the wall of the intestine.
It should be recognized that any oral drug entering the plasma in blood vessels within the gastrointestinal tract is directed first to the …..before being delivered to other tissues and organs of the body.
liver (where the drug may be removed from the plasma and metabolized)
Removal and metabolism (by the liver) of drug, which has just been absorbed from the gastrointestinal tract, before reaching other organs is often referred to as?
the "first pass effect".
For some drugs the "first pass effect" is?
quite large (a high percentage of drug being absorbed from the gastrointestinal tract is removed by the liver before reaching other organs) but for other drugs the "first pass effect" is not significant.
What is Sublingual Administration?
the intention is that the drug be absorbed into (the plasma within blood vessels passing through the surface of the underside of the tongue) or of the cheek.
Drug entering the circulation in the tongue or the inside of cheek is directed first to?
the heart.
drug administered to the skin or the mucosal surfaces of the nasal passages or the lungs or injected intravenously will also be directed first to?
the heart.
Sublingual admin., to the skin or the mucosal surfaces of the nasal passages or the lungs or injected intravenously delivery of a drug to the heart can be?
extremely useful - in the case of a drug with a targeted therapeutic effect in the heart –
but can be problematic - in the case of a drug which can produce undesired actions in the heart.
What is Intragastric Tube Administration?
the drug be delivered (in liquid form only) directly into the stomach. This route of administration is useful in unconscious individuals or in individuals who have difficulty swallowing or inability to swallow.
What is Rectal Administration?
the drug to be delivered into the lumen of the colon. Drugs delivered in this manner can be absorbed into the plasma of the systemic circulation or may have effects only within the colon.