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80 Cards in this Set
- Front
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Cmax |
Rate and extent |
|
Area Under Curve |
Extent Most important |
|
Tmax |
Time required to reach the plasma concentration Rate |
|
Absolute Bioavailability |
Fabs= AUC (test product/non IV) / AUC (IV) |
|
Relative Bioavailability |
F rel = AUC (test product) / AUC (non IV reference) |
|
High protein/high fat meal |
⬆️GET = ⬇️ Absorption |
|
Lying on the left side |
⬆️GET = ⬇️ Absorption |
|
Diabetic gastroparesis |
⬆️GET = ⬇️ Absorption |
|
Gastric ulcer |
⬆️GET = ⬇️ Absorption |
|
Heavy exercise |
⬇️Perfusion = ⬆️GET = ⬇️ Absorption |
|
Antidiarrheals |
⬆️GET = ⬇️ Absorption |
|
Opioids |
⬆️GET = ⬇️ Absorption |
|
Anticholinergics |
⬆️GET = ⬇️ Absorption |
|
Extreme temp of food (very hot and very cold) |
⬇️GET = ⬆️Absorption |
|
Lying on the right side |
⬇️GET = ⬆️Absorption |
|
Gastroctectomy |
⬇️GET = ⬆️Absorption |
|
Duodenal ulcer |
⬇️GET = ⬆️Absorption |
|
DM |
⬇️GET = ⬆️Absorption |
|
Mild exercise |
⬇️GET = ⬆️Absorption |
|
Prokinetics agents |
⬇️GET = ⬆️Absorption |
|
Erythromycin |
⬇️GET = ⬆️Absorption |
|
Albumin |
Blood protein for weak acids |
|
a1 acid glycoprotein |
Blood protein for weak bases |
|
Globulin |
Blood protein for hormones |
|
Highly protein drugs |
Diazepam, Digitoxin, indomethacin, tolbutamide, warfatin, midazolam |
|
High Vd |
Atropine Chloroquine Digoxin Fluoxetine Imipramine TCAs BBs |
|
Low VD |
Warfarin Midazolam Valproic Acid Chloropropamide Furosemide Tolbutamide |
|
Drugs with ⬆️FPE |
Atropine Opioids Epinephrine B-blockers |
|
Drugs that undergo Glucoronidation |
Acetaminophen Diazepam Chloramphemicol Digoxin Morphine |
|
Class 1A Antiarrhythmics |
Na channel blockers "Double Quarter Pounder" Disopyramide Quinidine Procainamide |
|
Class 1b Antiarrhytmics |
"Lettuce Tomato Mayonaisse Potato"
Lidocaine Tocainamide Mexiletine Phenytoin |
|
Class Ic Anti arrhythmics |
"More Fries Please, Enge"
Moricizine Flecainide Propafenone Encainide |
|
Submucosal plexus |
Meissner's plexus Control secretion of substances |
|
Myenteric plexus |
Auerbach's plexus Motility |
|
Only B2 agonist used in symptomatic bradycardia |
Terbutaline |
|
Non selective B agonist |
Isoproterenol |
|
Dobutamine |
B1 agonist |
|
1st line agent for cardiogenic shock |
Dobutamine |
|
Prodrug of Epinephrine used against glaucoma |
Dipivefrin |
|
Phenylephrine |
a-1 agonist |
|
Propylhexedrine |
a-1 agonist |
|
Methoxamine |
a-1 agonist |
|
Oxymetazoline |
a-1 agonist |
|
Tetrahydrozoline |
a-1 agonist |
|
Nafazoline |
a-1 agonist |
|
Presynaptic a2 agonists |
Clonidine Methyldopa Guanfacine Guanabenz |
|
Postsynaptic a2 agonist |
Apraclonidine Brimonidine |
|
Treatment for ADHD but w/ lesser effects |
Atomoxetine |
|
Inhibits the tyrosine hydroxylase/formation of L-dopa |
Metyrosine |
|
Inhibits the release of dopamine |
Reserpine |
|
Inhibits the exocytosis/ Release of NE |
Guanethedine Guanadrel Bretylium |
|
VMAT blocker |
Reserpine |
|
NE transporter blocker |
Guanethedine |
|
Inhibit reuptake process |
Norepinephrine Tricyclic Antidepressant Cocaine |
|
Stimulate of release process of NT |
Amphetamine Ephedrine Tyramine Angiotensin II a- latrotoxin |
|
Drugs for Anaphylaxis |
Hydrocortisone Epinephrine Ranitidine Salbutamol Diphenhydramine |
|
Inhibits the synthesis of acetylcholine |
Hemicholinium |
|
Inhibits the uptake into strorage vesicles of Ach |
Vesamicol |
|
Inhibits the release of Ach |
Botilinium toxin |
|
Stimulates the release of Ach |
Spider venom |
|
Ethanolamine |
Diphenhydramine (Benadryl®️) Dimenhydrinate |
|
Ethylenediamine |
Tripenelamine |
|
Piperazine - histamine antagonist |
Hydroxyzine (Iterax) Meclizine (Bonamine) |
|
Alkylamine |
Brompheniramine Chlorpheniramine (Chlorphenamine) |
|
Phenothiazine |
Promethazine (Phenergan) |
|
Piperidine - Histamine Antagonist |
Cyproheptadine |
|
Inhibits the K in H/K+ ATPase |
Vonoprazan |
|
Partial agonist of 5-HT1a |
Buspirone |
|
5HT1d agonist |
"triptans" Sumatriptan Naratriptan |
|
5HT2 Agonist |
Ergotamine Ergonovine Ergometrine |
|
5HT2 Antagonist |
Methylsergide |
|
5HT3 Antagonist |
Ondansetron Granisetron |
|
5HT4 agonist |
Tegaserod |
|
Management of pulmonary HTN |
Epoprostenol |
|
Used against erectile dysfunction |
Alprostadil |
|
Cytoprotectant for acid related disorder, abortifacient, ⬆️uterine contraction |
Misoprostol (Cytotec) |
|
⬆️Uterine contraction, promote cervical dilation Alternative to misoprostol |
Dinoprostone |
|
Used against glaucoma S/E: lengthening of eyelashes |
Lanatoprost |
|
Treatment for HTN urgency |
PO: Nufedipine Captopril Clonidine IV: Nicardipine |
|
Parameter for LMWH |
Anti factor Xa assay |