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80 Cards in this Set

  • Front
  • Back

Cmax

Rate and extent

Area Under Curve

Extent


Most important

Tmax

Time required to reach the plasma concentration


Rate

Absolute Bioavailability

Fabs= AUC (test product/non IV) / AUC (IV)

Relative Bioavailability

F rel = AUC (test product) / AUC (non IV reference)

High protein/high fat meal

️GET = ⬇️ Absorption

Lying on the left side

⬆️GET = ⬇️ Absorption

Diabetic gastroparesis

⬆️GET = ⬇️ Absorption

Gastric ulcer

⬆️GET = ⬇️ Absorption

Heavy exercise

️Perfusion = ⬆️GET = ⬇️ Absorption

Antidiarrheals

⬆️GET = ⬇️ Absorption

Opioids

⬆️GET = ⬇️ Absorption

Anticholinergics

⬆️GET = ⬇️ Absorption

Extreme temp of food (very hot and very cold)

⬇️GET = ⬆️Absorption

Lying on the right side

⬇️GET = ⬆️Absorption

Gastroctectomy

⬇️GET = ⬆️Absorption

Duodenal ulcer

⬇️GET = ⬆️Absorption

DM

⬇️GET = ⬆️Absorption

Mild exercise

⬇️GET = ⬆️Absorption

Prokinetics agents

⬇️GET = ⬆️Absorption

Erythromycin

⬇️GET = ⬆️Absorption

Albumin

Blood protein for weak acids

a1 acid glycoprotein

Blood protein for weak bases

Globulin

Blood protein for hormones

Highly protein drugs

Diazepam, Digitoxin, indomethacin, tolbutamide, warfatin, midazolam

High Vd

Atropine


Chloroquine


Digoxin


Fluoxetine


Imipramine


TCAs


BBs

Low VD

Warfarin


Midazolam


Valproic Acid


Chloropropamide


Furosemide


Tolbutamide

Drugs with ⬆️FPE

Atropine


Opioids


Epinephrine


B-blockers

Drugs that undergo Glucoronidation

Acetaminophen


Diazepam


Chloramphemicol


Digoxin


Morphine

Class 1A Antiarrhythmics

Na channel blockers



"Double Quarter Pounder"



Disopyramide


Quinidine


Procainamide

Class 1b Antiarrhytmics


"Lettuce Tomato Mayonaisse Potato"



Lidocaine


Tocainamide


Mexiletine


Phenytoin

Class Ic Anti arrhythmics

"More Fries Please, Enge"



Moricizine


Flecainide


Propafenone


Encainide

Submucosal plexus

Meissner's plexus



Control secretion of substances

Myenteric plexus

Auerbach's plexus



Motility

Only B2 agonist used in symptomatic bradycardia

Terbutaline

Non selective B agonist

Isoproterenol

Dobutamine

B1 agonist

1st line agent for cardiogenic shock

Dobutamine

Prodrug of Epinephrine used against glaucoma

Dipivefrin

Phenylephrine

a-1 agonist

Propylhexedrine

a-1 agonist

Methoxamine

a-1 agonist

Oxymetazoline

a-1 agonist

Tetrahydrozoline

a-1 agonist

Nafazoline

a-1 agonist

Presynaptic a2 agonists

Clonidine


Methyldopa


Guanfacine


Guanabenz

Postsynaptic a2 agonist

Apraclonidine


Brimonidine

Treatment for ADHD but w/ lesser effects

Atomoxetine

Inhibits the tyrosine hydroxylase/formation of L-dopa

Metyrosine

Inhibits the release of dopamine

Reserpine

Inhibits the exocytosis/ Release of NE

Guanethedine


Guanadrel


Bretylium

VMAT blocker

Reserpine

NE transporter blocker

Guanethedine

Inhibit reuptake process

Norepinephrine


Tricyclic Antidepressant


Cocaine

Stimulate of release process of NT

Amphetamine


Ephedrine


Tyramine


Angiotensin II


a- latrotoxin

Drugs for Anaphylaxis

Hydrocortisone


Epinephrine


Ranitidine


Salbutamol


Diphenhydramine

Inhibits the synthesis of acetylcholine

Hemicholinium

Inhibits the uptake into strorage vesicles of Ach

Vesamicol

Inhibits the release of Ach

Botilinium toxin

Stimulates the release of Ach

Spider venom

Ethanolamine

Diphenhydramine (Benadryl®️)


Dimenhydrinate

Ethylenediamine

Tripenelamine

Piperazine - histamine antagonist

Hydroxyzine (Iterax)


Meclizine (Bonamine)

Alkylamine

Brompheniramine


Chlorpheniramine (Chlorphenamine)

Phenothiazine

Promethazine (Phenergan)

Piperidine - Histamine Antagonist

Cyproheptadine

Inhibits the K in H/K+ ATPase

Vonoprazan

Partial agonist of 5-HT1a

Buspirone

5HT1d agonist

"triptans"



Sumatriptan


Naratriptan

5HT2 Agonist

Ergotamine


Ergonovine


Ergometrine

5HT2 Antagonist

Methylsergide

5HT3 Antagonist

Ondansetron


Granisetron

5HT4 agonist

Tegaserod

Management of pulmonary HTN

Epoprostenol

Used against erectile dysfunction

Alprostadil

Cytoprotectant for acid related disorder, abortifacient, ⬆️uterine contraction

Misoprostol (Cytotec)

️Uterine contraction, promote cervical dilation


Alternative to misoprostol

Dinoprostone

Used against glaucoma


S/E: lengthening of eyelashes

Lanatoprost

Treatment for HTN urgency

PO: Nufedipine


Captopril


Clonidine



IV: Nicardipine


Parameter for LMWH

Anti factor Xa assay