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32 Cards in this Set
- Front
- Back
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What do most osteoporosis drugs do?
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these mostly prevent resorption
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What does PTH do? what stimulates its release?
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this is stimulated when calcium is low
increases circulating calcium |
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What does vitamin D do?
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this increases circulating calcium
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What do PTD and Vit D work through?
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these both work thought RANK ligand
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what is the definition of osteoporosis?
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impaired trabecular bone
thin and porous cortical bone weak and more likely to fracture |
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Who is most at risk for osteoporosis?
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post menopausal women
long term glucocorticoid use thyrotoxicosis alcoholism malabsoprtion syndromes |
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What are the three general treatments for osteoporosis?
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estrogen and SERM
calcium and various drugs |
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What is the RDA of calcium?
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1000mg (elemental calcium is whats used by body)
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Is calcium enough to treat osteoporosis?
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no, but it is needed for all other tx to work
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how does calcium prevent osteoporosis?
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probably inhibits PTH secretion
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what are the adverse effects of calcium administration?
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this can inhibit iron absorption
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What is Vit D required for in the GI?
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this is required for adequate absorption of calcium
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What does Calcitonin do?
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this inhibits bone resorption of calcium and phosphate by osteoclasts
antagonizes actions of parathyroid hormone |
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How is Calcitonin given?
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intranasally or Injection
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What are the possible adverse effects of Calcitonin?
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Allergic Rxns
rhinitis/sinusitis N/V |
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What is Teriparatide?
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this is recombinant parathyroid hormone
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How is Teriparatide given?
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this is given as intermittent spikes of PTH
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What does Teriparatide treat?
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this treats osteoporosis
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What is the ONLY anabolic osteoporsis therapy?
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Teriparatide
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What are the major dangers of Teriparatide use?
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Osteosarcoma can be possible
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What kind of drug is Densoumab?
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this is a monoclonal antibody against RANKL
-inhibits bone resorption |
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What is RANK-L used for normally?
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this is used for the formation of mature osteoclasts
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What is Densoumab used to treat?
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this treats severe osteoporosis in postmenopausal women
increases bone strength and mass |
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What is the one absolute contraindication of Densoumab use?
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hypocalcemia
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What do all the bisphosphonates named end in?
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-ronate
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What do all bisphosphonates do?
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these are inhibit osteoclast activity, and stengthen bone
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how do bisphosphonates work?
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these bind calcium salts by substituting for the phosphate molexule.
this inhibits formation, aggregation, and dissolution of hydroyapatie crystals in bone |
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What do bisphosphonates treat?
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first line treatment of osteoporosis in men and women
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How are bisphosphonates dosed?
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2 hours before breakfast, with a cup of water.
pt has to sit upright for 30-60 min very poorly absorbed |
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What are the adverse effects of bisphosphonates? (the -ronate drugs)
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abdominal pain, upper GI irritation, esophageal ulcers, constipation, diarrhea, flatuence
N/V |
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What can happen with bisphosphonates after jaw surgery?
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osteonecrosis
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What kind of drug is Cinacalcet?
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this is a calcmimetic drug
blocks PTH release |
