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4 Cards in this Set
- Front
- Back
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3 Essential Features of Receptors (targets for drugs)
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-must be biologically important molcules
-must have structural features that permit drug specificity -must have drug binding site & biologically active site |
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Effector Site Blocking Action
-Define |
occurs when a drug competes with a substrate at the catalytic site
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Conformational Induction (Direct Allosteric Effect)
-Define |
occurs when a drug binds at a site other than the effector site and cases a conformational change that leads to either allosteric activation or inhibition
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Conformational Selection (Indirect Allosteric Effect)
-Define |
occurs if a R has 2 forms (active & inactive) and the drug causes an increase of one of the forms (e.g. by binding to active form and stabilizing it or by removing active Rs so body produces more to balance out)
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