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12 Cards in this Set
- Front
- Back
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Cyclophosamide Mechanism, application, side effect, type |
Cross-linking of DNA, Leukemia, myelosuppresion and secondary tumors, Alkylating Agent |
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Methotrexate Mechanism, application, side effect, type |
Reduction of folic acid, combination treatments, myelosuppresion, metabolite |
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5-Flurouracil Mechanism, application, side effect, type |
Interferes with conversion of deoxyuridylate to deoxythmidylate, blocks S phase, myelosuppresion and hepatotoxicity, antimetabolite |
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Doxorubicin Mechanism, application, side effect, type |
Use of superoxide to cause strand breaks blood cancer, sarcomas, adenocarcinomas Cardiotoxicity Intercalating |
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Bleomycin Mechanism, application, side effect, type |
Iron-chelating, creates superoxide by forming Fe3+ Hematopoetic and squamous cell cancers Hyperpigmentation Intercalating |
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Gemcitabine Mechanism, application, side effect, type |
Use of two flourines to stop DNA synthesis N/A N/A Intercalating |
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Taxanes Mechanism, application, side effect, type |
Prevent breaking down of microtubles Metastatic adenocarcinomas Neurotoxic and alopecia Microtubule-based |
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Vinca Alkaloids - Vincristine/Vinblastine Mechanism, application, side effect, type |
Prevent initiation formation of microtubules Hematalogic cancers and solid epithelia carcinomas Myelosuppression and alopecia Microtubule-based |
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Anthracylines - Doxorubicin, podophyllins Mechanism, application, side effect, type |
Prevent the resealing after the cutting of topoisomerase II (Etoposide) First line of treatment of small cell lung cancer. Myelosuppression and alopecia Topisomerase inhibitor |
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Camptothecins Mechanism + Two molecules, Toxicity, Type |
Bind to Topo 1: DNA Complex Topotecan and Irinotecan (Prodrug) Myelosuppression and Neutropenia Topisomerase inhibitor |
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Cisplatin Mechanism, Type |
Binds to Guanine N7 position and causes cell death Platinum Drug
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Oxaliplatin Mechanism, application, side effect, type |
Recruitment of HMG to cause cell kink and eventually death Last option type treatment Myelosuppresiom and renal failure Platinum Drug |
