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12 Cards in this Set
- Front
- Back
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a class of drug that has analgesic, antiseptic and anti-inflammatory properties. Function: to reduce pain and inflamm |
Non-steroidal Anti-inflammatories NSAIDs |
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Describe the inflammation Process |
1. Cell disruption due to a trauma 2. free phospholipids 3. Conversion of phospholipidase to arachidonic acid 4. COX 1 and 2 production 5. Prostaglandin production leading to inflammation signs |
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What are the main side-effects of NSAID use? |
- gastric ulceration - reduced clotting ability - dehydration that will result in kidney failure |
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What are the 3 main synthetic corticosteroids? |
Dexamethasone Prednisolone Methylprednisolone |
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Identify a natural corticosteroid |
Cortisol |
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A class of crticosteroid Suppress inflammation and immunity by inhibiting phospholipidase A2 Assist in breakdown of fats and CHOs and proteins |
Glucocorticoid |
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A class of corticosteroid Regulate the balance of salt and water in body NA retention by renal tubule Increase K excretion via urine |
Mineralocorticoids |
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What are the 2 types of fluids used in fluid therapy? |
Crystalloids (small molecules) and Colloids (large molecules and cels) |
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Give an example of a natural colloid: |
Albumin, syn in the liver and is water sol. |
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Why is fluid therapy a useful tool? |
To correct deficits & abnormalities (anaemia, glucose, electrolyte etc) Replace ongoing losses Maintain normal levels |
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Which COX? Helps clotting in blood vessels Increases blood flow to kidney during dehydration Lines GIT General "housekeeping" and immune protection Increases side effects of NSAIDS if inhibited |
COX 1 |
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Which COX? Induced after an insult Results in inflammation, pain and pyrexia Selectively preferred to inhibit inflammation |
COX 2 |
