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23 Cards in this Set
- Front
- Back
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Bevacizumab |
(Avastin) Anti-metastasis, anti-angiogenesis |
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Thalidomide |
Anti-metastasis, anti-angiogenesis |
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Ondansetron |
Anti-vomiting adjuvent, 5-HT3 serotonin |
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Acute tissue toxicity |
nausea, vomiting, BM suppression |
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delayed tissue toxicity |
leukemia, cardio-toxicity(anthracyclines) |
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Dexrazosane |
anti-free radical for cardio-toxicity by anthracyclines |
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Strong tendency for nausea and vomiting |
cisplatin, dacarbazine, mechlorethamine, cyclophasphamide, doxoruicin, lomustine, carmustine |
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survival shoulder |
drugs won't have an effect until certain level of drug concentration is reached |
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cancer drug classes that affects the cell cycle to induce cell death |
anti-metabolites, plant alkaloids |
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alkylating agents |
DNA alkylating, +ring to cause cross-linking of pyrimidine and purine |
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Cyclophosphamide |
alkylating nitrogen mustard, prodrug that needs CYP450 of liver for activation |
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Ifosfamide |
Cyclophosphamide analog, also a alkylating nitrogen mustard prodrug |
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nitrogen mustards side effect and resistance |
1. toxic acrolein that cause hemorrhagic cystitis, treated by MESNA 2. delayed type toxicity of leukemia 3. requires carriers on cell membrane that leads to resistance |
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Temozolomide |
alkylating nitrosourea 1. passes through BBB 2. first choice for treating brain tumor(oral, one and only for brain tumor) |
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Cisplatin, Carboplatin, Oxaliplatin |
alkylating related agents 1. contains Pt 2. ototoxic and nephrotoxic, therefore, needs mannoitol of 01.% NaCl as adjuventing dilution |
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Cisplatin |
testis, ovary, bladder, lung cancer |
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Carboplatin |
lung cancer |
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Oxaliplatin |
colorectal cancer |
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anti-metabolites |
1 analogs to folic acid, pyrimidines, purines 2. affects S phase 3. BM suppression 4. Xanthine oxidase, HGPRT |
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Xanthine Oxidase |
metabolizes DNAs into uric acid |
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Allopurinol |
Xanthine oxidase inhibitor |
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HGPRT |
metabolizes purines and pyrimidines |
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Ocarina |
Ocarina |
