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7 Cards in this Set
- Front
- Back
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What is biotransformation in drug metabolism in liver? |
Combination of phase 1 & phase 2 reactions |
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Describe what happens in a phase 1 reaction |
Either reduction, oxidation or hydrolysis. The products are often more toxic and reactive than reactants |
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What occurs in a phase 2 reaction? |
Conjugation of a water-soluble group (like gluconoride) to a drug. Products end up being more soluble & less toxic than reactants |
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Why is there genetic variation in drug metabolism? |
Due to different versions of cytochrome C450 being expressed |
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How does the liver process drugs? |
Liver transfers drugs from plasma to bile. Bile → gall bladder → duodenum → drug reabsorbed into blood, if not lost in faecal excretion |
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How does the kidney process drugs? |
Filtered by glomerulus |
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Differences in reabsorption between lipid-soluble/water-soluble drugs? |
Lipid-soluble drugs more likely to be reabsorbed, water-soluble more likely to be excreted |
