Pharmacology

Front 1

4 Typical antipsychotics (neuroleptics)

Back 1

Thioridazine
Haloperidol
Fluphenazine
Chlorpromazine

Front 2

Mechanism of typical antipsychotics

Back 2

Block D2 receptors

Front 3

4 Clinical uses of typical antipsychotics

Back 3

1. Schizophrenia
2. Psychosis
3. Acute mania
4. Tourette Syndrome

Front 4

3 categories of side effects of typical antipsychotics.

Back 4

1. Extrapyramidal system/endocrine (hyperprolactinemia, dry mouth, constipation, hypotension, sedation.
2. Neuroleptic malignant syndrome (rigidity, myoglobinuria, autonomic instability, hyperpyrexia.
3. Tardive dyskinesia (stereotypic oral-facial movements; assoc c long-term use)

Front 5

3 atypical antipsychotics

Back 5

1. Clozapine
2. Olanzapine
3. Risperidone
(It's not atypical for OLd CLOsets to RISPER

Front 6

Mechanism of atypical antipsychotics

Back 6

Block 5-HT2 and DA receptors.

Front 7

Clinical use of atypical antipsychotics.

Back 7

+/- symptoms of schizophrenia.
Olanzapine also used for OCD, anxiety, depression, mania, Tourette's.

Front 8

Advantage of atypical antipsychotics over typical.

Back 8

Fewer extrapyrimidal and anti-cholinergic side effects.

Front 9

Toxicity associated with Clozapine.

Back 9

Agranulocytosis.

Front 10

Side effects of Lithium

Back 10

(LMNOP)
Movement (tremor)
Nephrogenic DI (ADH antagonist)
HypOthyroidism
Pregnancy problems.

Front 11

Clinical use of Buspirone

Back 11

Anxiolysis. Does not cause sedation or addiction, nor does it interact with alcohol.

Front 12

Mechanism of buspirone.

Back 12

Stimulates 5-HT1A receptors.

Front 13

4 classes of antidepressants.

Back 13

1. SSRIs
2. Tricyclic
3. Heterocyclic
4. MAOIs

Front 14

4 SSRIs.

Back 14

1. Fluoxetine
2. Sertraline
3. Paroxetine
4. Citalopram

Front 15

Clinical use of SSRIs.

Back 15

Depression, OCD.

Front 16

Side effects of SSRIs.

Back 16

GI distress, anorgasmia.

Front 17

What is Serotonin syndrome?

Back 17

If SSRIs administered with MAOIs, hyperthermia, muscle rigidity, cardiovascular collapse.

Front 18

6 Tricylic antidepressants.

Back 18

1. Imipramine
2. Desipramine
3. Clomipramine.
4. Amitriptyline
5. Nortriptyline
6. Doxepin

Front 19

Mechanism of antidepressants.

Back 19

Block reuptake of NE and serotonin.

Front 20

Tricylic used for bedwetting.

Back 20

Imipramine
"I'm about to wet the bed"

Front 21

Trycyclic used for OCD.

Back 21

Clomipramine.

Front 22

3 Side effects of tricyclics.

Back 22

1. Sedation
2. alpha-blocking effects
3. Anticholinergic side effects (tachycardia, urinary retention)

Front 23

Which tricyclics have more anticholinergic side effects?

Back 23

Tertiary (amitripyline) > Secondary (nortriptyline)

Front 24

Which TCA is the least sedating?

Back 24

Despiramine

Front 25

Toxicity of TCAs/

Back 25

Tri-C's:
1. Convulsions
2. Coma
3. Cardiotoxicity
Also respiratory depression and hyperpyrexia.
In elderly, confusion/hallucinations d/t anticholinergic side effects.

Front 26

Which TCA is best to use in the elderly?

Back 26

Nortripyline. Less anticholinerigc side effects.

Front 27

5 Heterocylic antidepressants.

Back 27

1. Buproprion
2. Venlafaxine
3. Mirtazapine
4. Maprotiline
5. Trazodone
(You need BUtane in your VEINs to MURder for a MAP of alcaTRAZ.)

Front 28

Toxicity of bupropion.

Back 28

Tachycardia, insomnia, headache, seizure in bulemic pts.No sexual side effects.

Front 29

Mechanism and uses of Venlafaxine.
Also toxicities.

Back 29

GAD, depression.
Inhibits 5-HT, NE, DA reuptake.
Stimulant effects, sedation, nausea, constipation, increased BP.

Front 30

Mechanism of Mirtazapine.

Back 30

alpha2 antagonist (increases NE and serotonin release) + potent 5-HT2 and 5-HT3 antagonist.

Front 31

4 Toxicities of Mirtazapine.

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1. sedation
2. increased appetite.
3. weight gain.
4. dry mouth.

Front 32

Mechanism of Maprotiline.

Back 32

Blocks NE reuptake.

Front 33

2 toxicities of Maprotiline.

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1. Sedation
2. Orthostatic hypotension.

Front 34

Mechanism of Trazodone.

Back 34

Inhibits 5-HT reuptake.

Front 35

4 toxicities of Trazodone.

Back 35

1.sedation
2. nausea
3. priapism
4. postural hypotension

Front 36

Name 2 MAOIs.

Back 36

1. Phenelzine.
2. Tranylcypromine.

Front 37

Clinical use of MAOIs.

Back 37

Atypical depression (with psychotic or phobic features), anxiety, hypochondriasis.

Front 38

Toxicity of MAOIs.

Back 38

Hypertensive crisis with tyramine ingestion and meperidine.
CNS stimulation.

Front 39

Contraindications of MAOIs.

Back 39

Don't admin with SSRIs or beta-agonists (to prevent serotonin syndrome).