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11 Cards in this Set
- Front
- Back
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Give relationship b/w NNT, NNH, ARR, AHI
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NNT=1/ARR
NNH=1/AHI |
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What are some limitations of risk-benefit ratios?
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fails to consider: 1) nature of the risks or benefits
2) prevision or uncertainty of the incremental risks and benefits 3) risk preference of decision maker 4) risk and benefits concurrently (only can talk about them separately ie. give an uncertainty around risk or around benefit but not around both at the same time) |
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How do you calculate incremental risk benefit ratio?
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same as ICER except cost is risk, effectiveness is risk
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on a risk benefit plane, label the axis
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y is risk/harm, x is effectiveness
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what is a confidence box?
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it's when you give the uncertainty around the benefit and the uncertainty around the risk and you box it so that it's not just a dot in one quadrant anymore but could be in multiply quadrants and therefore effects your decision
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Why can't we just do confidence boxes instead of monte carlo simulations?
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Because with boxes we know that 95% of the time the dot will fall in the box but we don't know where the dots will fall in the box
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What are the steps in a 2nd order Monte Carlo simulation?
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assign beta distributions around all probabilities
makes ie. 3000 replications of the study calculate IRBR for each replication plot the dots on the risk-benefit plane plot the results in the risk benefit acceptability curve |
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Label the axis for risk benefit acceptability curve
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y axis is probability, x axis is risk benefit acceptability
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explain the net benefit framework
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usually a decision to adopt is if there is less increase in risk than increase in benefit.
Propose it should be that the increase in risk/increase in benefit ratio is less than what is ACCEPTABLE (u) this can be rearranged into a linear expression, have variance included, graphed, and your y-intersect is your net benefit. |
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Explain the equation for a INB using discrete event simulation
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INB=[the utility of one treatment minus the other] minus [the probability of each adverse event times the disutility of that adverse event]
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what is a discrete choice experiment?
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allows the evaluation of patients' preferences through the administration of a questionnaire-based survey
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