Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
25 Cards in this Set
- Front
- Back
|
What are the steps for preparing the drug sample for testing |
1.sample collection 2.release drug from matrix 3.liquid handling 4.removal of endogenous compounds 5.enhance the sensitivity and selectivity of drug |
|
|
What are matrixes and how do you release them |
Matrixes are proteins bound to drugs and to release the drug from the matrix to u can do it by hydrolysis |
|
|
Other than hydrolysis what other methods can you use to release the drug from the matrix |
So I cation Dilution Heating |
|
|
What does the liquid handling step mean |
It involves the removal adding mixing or separation of liquids |
|
|
How do you remove the endogenous compounds |
Precipitation Ultra filtration Membrane extraction Liquid liquid extraction |
|
|
How do you increase the sensitivity of the drug and how |
Using derivatization ,it is a process to make the chemical compound into a similar structure to make it easier to be detected by certain analytical equipment |
|
|
What are the location you can get drug samples |
-raw materials -in or on line pharmaceutical products Products after packing -packaging materials |
|
|
What forms can the drugs come in |
Powder Liquid Semi solid like creams and paste |
|
|
What is the advantage of using disposable sampling tools |
No risk of cross contamination No cleaning required before or after use No cleaning cost Saves time and money |
|
|
What are the types sampling tools used for drugs |
-sampling scoop -sample thieves -dip tube -sampling spear |
|
|
When do you use a sampling scoop |
For solid materials |
|
|
When do you use a sample thieve |
For deep containers filled with solids like pills |
|
|
When do you use a dip tube |
Used to sample liquid medicine |
|
|
When do you use a sample spear |
When the sample is in a bag so can penetrate easily to collect sample easily |
|
|
For the meds stability it may degrade so what is the maximum amount of change allowed |
Only up to A 5 percent change from its orignal value during storage |
|
|
What container and what should you take notes about the container holding the sample |
Use a Amber glass bottle ,protect the sample from light air and moisture and that the container is sealed Take precautions for any spillage or breakage Maintain the temperature and humidity during storage and transportation |
|
|
How should the liquid pharmaceutical sample be stored in the container |
The headspace should be kept to a minimum but not till it will overflow and the bottle must be closed tightly |
|
|
For liquid medicine sample why must the head space be kept to a minium |
To minimise any possible degradation in the air |
|
|
For solid medicine samples how should it be stored in the container |
Fill the container totally with the sample and then use cotton to fill up any remaining space |
|
|
What are types of test you can do to medicine |
Microbiological Chemicals Preservatives Functionality |
|
|
What is the space in the container between the liquid surface and the cap |
Headspace |
|
What sampling tool is this |
A sampling scoop |
|
What sampling tool is this |
A sample thieve |
|
What sampling tool is this |
A dip tube |
|
What sampling tool is this |
A sampling spear |
