Pharm Winter 2

Front 1

Esters (Local anesthetics)

Back 1

Procaine, Tetracaine, Benzocaine, Cocaine

Front 2

Amides (Local anesthetics)

Back 2

Lidocaine, Prilocaine, Bupivacaine, Ropivacaine

Front 3

Short-acting local anesthetics

Back 3

Procaine, Tetracaine

Front 4

Intermediate-acting local anesthetics

Back 4

Lidocaine, Prilocaine

Front 5

Long-acting local anesthetics

Back 5

Bupivacaine, Ropivacaine

Front 6

First anesthetic developed

Back 6

Procaine

Front 7

Like procaine but 10x more potent/toxic and longer acting

Back 7

Tetracaine uses/PHK

Front 8

OTC topical anesthetic

Back 8

Benzocaine

Front 9

Causes methemoglobinemia

Back 9

Prilocaine

Front 10

Most likely to cause arrythmias

Back 10

Bupivacaine

Front 11

Enantiomer of Bupivacaine, more lipid soluble, less cardiac effects

Back 11

Ropivacaine

Front 12

Active form of local anesthetics

Back 12

Ionized (weak bases)

Front 13

local anesthetic target fibers

Back 13

Type A delta, Type C dorsal root, sympathetic

Front 14

Toxicity of ester local anesthetics

Back 14

PABA can cause allergic rxns and inhibit sulfonamides

Front 15

Mechanism of local anesthetics

Back 15

Block voltage gated sodium channels

Front 16

Thromboxane actions

Back 16

Vasoconstriction (+mitogenic)
Bronchoconstriction
Activate GI tract, increase mucus, decrease acid
Platelet aggregation

Front 17

Prostacyclin actions

Back 17

Vasodilation
Bronchodilation
Activate GI tract, increase mucus, decrease acid
Inhibits platelet activation
Vasodilation of renal arteries

Front 18

PGE1 actions

Back 18

Bronchodilation
Activate GI tract, increase mucus, decrease acid
Erection
Vasodilation of renal arteries
Fever

Front 19

PGE2 actions

Back 19

Vasodilation
Bronchodilation
Activate GI tract, increase mucus, decrease acid
Uterine contractions
Vasodilation of renal arteries
Pain, fever

Front 20

Dinoprosterone (PGE2)

Back 20

Abortion, facilitating labor, dysmenorrhea

Front 21

Alprostadil (PGE1)

Back 21

Erectile dysfunction
Patent ductus arteriosus

Front 22

Misoprostol (PGE1)

Back 22

Reduces gastric acid secretion for ulcers

Front 23

Epoprostenol (PGI)

Back 23

Vasodilation in pulmonary hypertension

Front 24

Zileuton & Zarfilukast

Back 24

Leukotriene antagonists used in asthma

Front 25

Celecoxib mechanism

Back 25

Reversible COX-2 inhibitor

Front 26

Celecoxib adverse effects

Back 26

May increase platelet aggregation
Contraindicated in sulfonamide sensitivity

Front 27

NSAID with most potency, but worse side effect profile

Back 27

Indomethacin

Front 28

NSAIDs that inhibit PMN migration

Back 28

Indomethacin, Piroxican

Front 29

NSAID used in combo w/misoprostol for arthritis

Back 29

Diclofenac (Voltaren)

Front 30

NSAID used in combo with opiates for post-surgical pain

Back 30

Ketorolac

Front 31

NSAID with best side effect profile, but shortest half-life

Back 31

Ibuprofen (1-3hrs)

Front 32

NSAID with longest half life

Back 32

Naproxen (13hrs)

Front 33

NSAID that is less nephrotoxic

Back 33

Suldinac

Front 34

Taken up by macrophages, suppresses phagocytosis and lysosomal enzymes

Back 34

Aurothioglucose

Front 35

Causes hemolysis in G6P deficient

Back 35

Hydroxychloroquine

Front 36

Distributes in retina and epidermins

Back 36

Hydroxychloroquine

Front 37

Most well tolerated drug for RA

Back 37

Sulfasaline - rare hepatitis or bone marrow suppression

Front 38

Murine/human MAB against TNF-a

Back 38

Infliximab

Front 39

MAB against CD20

Back 39

Rituximab

Front 40

Human MAB against TNF-a

Back 40

Adalimumab

Front 41

Recombinant protein TNF-a inhibitor

Back 41

Etanercept

Front 42

Recombinant protein, blocks T-cell activation

Back 42

Abatacept

Front 43

DHODH inhibitor

Back 43

Leflunomide

Front 44

IMPDH inhibitor

Back 44

Micophenolate mofetil

Front 45

Recombinant protein, IL-1 antagonist

Back 45

Anakira