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15 Cards in this Set
- Front
- Back
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2 direct thrombin inhibitors
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Lepirudin
Argatroban Derivd from the leech. Parenteral These drugs inhibit both solbule thrombin and thrombin enmeshed in developing clots. Monitor via aPTT. Alternative to heparin in heparin-induced thrombocytopenia. |
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Irreversible inhibition of ADP receptors.
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Ticlopidine
Clolpidrogrel. |
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Monoclonal antibody that reversibly inhibits fibrin:glycoprotein IIb/IIIa binding.
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Abciximab
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PD3/adenosine reuptake inhibitor used for anti-platelet action.
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Dipyridamole.
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Antiplasmoin agents used in acute bleeding episodes in hemophiliacs.
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Aminocaproic acid
Tranexamic acid. |
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Converts plasminogen to plasmin
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tTa(alteplase, reteplase, tenecteplase)
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Used in tx of HER2 breast cancer. Produces antiboedy to surface protein in cells that overepxress HER2.
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Trastuzumab
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Allopurinol is used adjunctive in cancer chemotherapy to offset hyperuricemia.
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Antmetabolite 6-MP
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antimetabolite that inhibits DNA polymerase.
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Cytarabine. Used in acute leukemias.
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Alkalating agent assoc with hemorrhagic cystitis.
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Cyclophosphamide
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Forms hydrogen peroxide & free radicals. Used in Hodgkins.
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Procarbazine.
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Inhibits thymidylase synthase
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5-FU. 5-fluorouracil
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M phase specific class of anticancer drugs.
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Alkaloids (vinblastine, etoposide, paclitaxel)
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Aromatase inhibitor that provents androstenedione to estrone conversion.
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Anastrozole.
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Inhibits Bcr-Abl. Used in CML.
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Imatinib
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