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15 Cards in this Set

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2 direct thrombin inhibitors
Lepirudin
Argatroban
Derivd from the leech.
Parenteral
These drugs inhibit both solbule thrombin and thrombin enmeshed in developing clots.
Monitor via aPTT.
Alternative to heparin in heparin-induced thrombocytopenia.
Irreversible inhibition of ADP receptors.
Ticlopidine
Clolpidrogrel.
Monoclonal antibody that reversibly inhibits fibrin:glycoprotein IIb/IIIa binding.
Abciximab
PD3/adenosine reuptake inhibitor used for anti-platelet action.
Dipyridamole.
Antiplasmoin agents used in acute bleeding episodes in hemophiliacs.
Aminocaproic acid
Tranexamic acid.
Converts plasminogen to plasmin
tTa(alteplase, reteplase, tenecteplase)
Used in tx of HER2 breast cancer. Produces antiboedy to surface protein in cells that overepxress HER2.
Trastuzumab
Allopurinol is used adjunctive in cancer chemotherapy to offset hyperuricemia.
Antmetabolite 6-MP
antimetabolite that inhibits DNA polymerase.
Cytarabine. Used in acute leukemias.
Alkalating agent assoc with hemorrhagic cystitis.
Cyclophosphamide
Forms hydrogen peroxide & free radicals. Used in Hodgkins.
Procarbazine.
Inhibits thymidylase synthase
5-FU. 5-fluorouracil
M phase specific class of anticancer drugs.
Alkaloids (vinblastine, etoposide, paclitaxel)
Aromatase inhibitor that provents androstenedione to estrone conversion.
Anastrozole.
Inhibits Bcr-Abl. Used in CML.
Imatinib