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6 Cards in this Set
- Front
- Back
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Why salt |
Higher absorption Higher permiability Higher bio availability Higher dissolution rate // Low chemical stability Hcl salts corrosive Addition step to make Lower percent API
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Preformulation properties |
Particle size Soluablity Dissolution rate Partition coefficient Ionisation Crystal properties Stability |
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Phase 1 trials |
Small does up to multiple doses Healthy volunteers |
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Phase 2 |
Asses efficacy |
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Phase 3 |
Large group efficacy Long term effects Tolerance Vs existing drugs |
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Stages to get to market (all) |
Discovery Decision to develop Animal / lab testing Approve human trials Phase 1-3 Review and approval Market Manufacturing |
