Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
34 Cards in this Set
- Front
- Back
|
Family of enzymes known for the preponderance of phase I metabolism.
|
cyp450s
|
|
|
CYP450s are present in:
|
Hepatocytes, small intestine, plasma, and lung
|
|
|
Altering ______ perfusion may alter metabolism.
|
Hepatic
|
|
|
Increased enzyme and/or supply
|
inducers
|
|
|
Decreased enzyme activity and/or supply
|
Inhibitors
|
|
|
Example of genetic alterations in enzymatic fx
|
Homozygous plasmacholinesterase (long effect to succs)
|
|
|
Dilantin, tobacco, phenobarb, st john's wort, aromatic hydrocarbons, carbamazepine, rifampin
|
p450 inducers
|
|
|
Cimetidine, allopurinol, MAOIs, EES, organophosphate, ketoconazole, grapefruit, SSRIs.
|
p450 inhibitors
|
|
|
A drug's non-ionized form is reabsorbed and recirculated until:
|
it is ionized enough for elimination
|
|
|
_____ trapping can alter elimination.
|
Ion
|
|
|
Example of ion trapping: _______ urine for TCA OD.
|
alkalinizing
|
|
|
Example of ion trapping: _________ trapped in fetal circulation d/t differences in maternal and fetal pH.
|
Local anesthetics
|
|
|
Some drugs are excreted as hydrophilic conjugates in bile, which can either be _____ or ______ by gut flora.
|
Eliminated or recycled
|
|
|
If gut flora is damaged, the _____ may not occur.
|
Recycling (think antibiotics)
|
|
|
Effect of mycin abx and NDNMBs
|
Inducer
|
|
|
Effect of ca channel blockers and NDNMBs
|
Increases blockade
|
|
|
Effect of lasix and NDNMBs
|
Increases blockade
|
|
|
Effect of echothiophate eye gtt and succs
|
Prolonged action
|
|
|
Dantrolene and lithium _____ paralytics
|
Potentiates
|
|
|
Effect of local anesthetics and NDNMBs
|
enhance blockade
|
|
|
Volatile anesthetics + paralytics =
|
complementary effect
|
|
|
Anticonvulsants and NDNMBs except miv and atracurium.
|
Resistant to blockade
|
|
|
Hypercalcemia ____ the response to NDNMBs.
|
Decreases
|
|
|
Hypermagnesemia ________ the effect of NDNMBs and succinylcholine.
|
Potentiates
|
|
|
Hypokalemia causes a ______ of cell membranes. This leads to a _____ to succs, and an _______ sensitivity to NDNMB.
|
Hyperpolarization; resistance; increased
|
|
|
Hyperkalemia causes a ________ of cell membranes. This leads to a _______ to NDNMBs, and an ________ sensitivity to succinylcholine.
|
Partial depolarization; resistance; increased
|
|
|
Methyl methacrylate and vascular endothelium-->
|
Hypotension and oxygenation issues
|
|
|
MAOIs + opioids =
|
Opioid potentiation
|
|
|
MAOIs + sympathomimetics =
|
HTN
|
|
|
MAOIs + demerol =
|
Serotonin syndrome
|
|
|
TCAs + barbiturates =
|
Additive CNS depression
|
|
|
TCAs + ketamine (in high doses) =
|
CV problems
|
|
|
Older anti-thyroid meds + morphine =
|
Sensitivity to depressant effects
|
|
|
Epi + halothane =
|
Cardiac dysrhythmias
|
