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42 Cards in this Set
- Front
- Back
mech of 5FU
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pyrimidine inhibits thimidylate synthase, decrease dTMP like MTX
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used for basal cell (topical)
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5FU
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use in CML
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busulfan
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SE busulfan
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pulmonary fibrosis and hyperpigmentation
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which Rx has SE irreversible myelosuppression
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5FU (v MTX myelosuppression which can reverse w leucovorin (folinic acid))
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what use in AML
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cytarabine
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what cyclophosphamide used for
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NHL, br, ovarian, immune
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used for HD
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ABVD (Doxorubican/Adriamycin, Bleo, Vinblastine, decarbazine)
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which Rx has SE megaloblastic anemia
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cytarabine (along with leukopenia, thrombocytopenia)
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what use in brain tumors
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nitrosureas
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SE cisplatin
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nephrotoxicity, acoustic nerve
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use cisplatin
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testicular, bladder, ovary, lung
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which Rx must be activated by HGPRTase
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6MP
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used with MTX
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5FU (they're synergistic)
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SE hemorrhagic cystitis
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cyclophosphamide (can be partially prevented with mesna)
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use of bleomycin
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testicular, lymphomas
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mech of cytarabine
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inhibits DNA polymerase
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4 Rx need bioactivation
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nitrosureas, cyclophosphamide (by liver), 5FU and 6MP
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dizziness, ataxia a SE for
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nitrosurea (cross BBB, CNS toxicity)
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specific mech of cyclophosphamide
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covalently x-link DNA at guanine N-7
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name some alkylating
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nitrosurea, cisplatin, cyclophosphamide, busulfan
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G2 specific Rx
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etoposide (inhibits topoisomerase II increases DNA degradation)
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Prednisone use cancer
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used in CLL, Hodgkins MOPP
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tamoxifen mech
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estrogen R mixed agonist/antagonist (SERM), effectively blocks binding of estrogen
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compare cyclophosphamide and cisplatin
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cyclophosphomide and cisplatin both alkylating agents, cyclo specif bind guanine N7 and require bioactiv, cyclo is used in NHL, Br, ovarian, immune while cisplatin is used in testicular, bladder, ovary and lung. SE of cyclo are myelosuppress and hemorrhagic cystitis, cisplatin is nephrotoxicity and acoustic nerve damage
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summary cyclo (mech, use, SE)
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alkylating agent binds guanine N7 and requires bioactiv
use: NHL, breast, ovarian, immune SE: myelosuppress, hemorrhagic cystitis |
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summmary cisplatin (mech, use, SE)
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alkylating agent used for testicular, bladder, ovary, lung with SE nephrotoxicity and acoustic nerve damage
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trastuzumab
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herceptin, monoclonal Ab ag her-2
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toxicity trastuzumab
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cardiotoxicity
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mech vincristine, vinblastin
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bind tubulin and block polymerization of microtubules (no mitotic spindle can form.
M phase specific |
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paclitaxel
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anti-cancer agent binds to tubulin so spindle cannot break down
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use paclitaxel
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anti-cancer for ovarian, breast
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toxicity paclitaxel
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myelosuppression, hypersensitivity
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use of vincristine, vinblastine
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lymphoma (MOPP), Wilm's tumor, choriocarcinoma
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tacrolimus
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FK506 binds to FK binding peotein, inhibits sxn IL2 and others
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use tacrolimus
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immune suppression in transplant
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toxicity tacrolimus
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nephrotox, peripheral neuro, HTN, pl eff, hyperglycemia
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mech azathioprine
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deriv 6MP interferes with syn and metab nucleic acids. toxic to prolifer lymphocytes
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use azathioprine
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kidney transplant, autoimmune (GN, AHA)
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mech cyclosporine
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binds cyclophilins, block diff and activ of T cells by inhibit production IL2 and its R
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use cyclosporine
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suppress organ rejection s/p transplant, some autoimmune
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toxicity cyclosporine
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nephtrotoxic (prevent w mannitol diuresis)
predisposal to viral infxn and lymphoma |