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45 Cards in this Set

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Epinephrine
1. á1, á2, â1, â2
Norepinephrine
2. á1, á2, â1 (no â2 activity)
GABA
3. Causes an inhibitory cell hyperpolarization
Muscarinic-r
4. Uses DAG & IP3 as 2nd messengers 5. Parasympathetic control
Bethanechol
6. Cholinergic. inc. GI & Bladder motility. Txt atonic bladder post-op
Pilocarpine
7. Cholinergic. Pupillary constriciton= miosis. Ciliary constriction= accomodation. 8. Txt acute glaucoma
Isoflurophate
9. Organophosphate. Irreversible acetylcholinesterase (-)r
Pralidoxime
10. “2PAM”. Reverses organophosphate binding to acetylcholinesterase
Neostigmine
11. Reversible acetylcholinesterase (-)r 12. Txt Myasthenia Gravis
Myasthenia Gravis
13. Anitbodies to Ach-r. inc. ‘g muscular weakness due to Ach ‘s weak postsynaptic effect @ NMJ. Inactivates-r
Tubocurium
14. Nondepol. Competitive cholinergic N-r (-)r. 15. Prevents Ach binding but does not activate NMJ 16. inc. Histamine release= dec. BP & inc. bronchospasm
Trimethaphan
17. Nonselectively binds N-r of the PS- and SNS
Pancurium
18. More potent than tubocurium w/o histamine release
Succinylcholine
19. Depol. Non competitive (-)r of muscle action 20. Opens Na Ch.= fasciculations. Closes Na Ch.= paralysis. Continuous infusion.
á1 & Eye
21. Mydriasis due to norepinephrine. Prazosin (-).
M-r & Eye
22. Miosis due to Ach. Atropine (-).
Sympathetic
23. Post ganglionic symapthetic fibers releases norepinephrine
Parasym.
24. Post ganglionic parasympathetic fibers release Ach
M3-r & Eye
25. Contracts sphincter = miosis. Contracts ciliary = accomodation.
M2-r & Heart
26. Negative chronotropy: dec. HR = vagal arrest 27. Negative inotropy: dec. contractility
M3-r & Lung
28. Bronchospasm inc.secretions
M3-r & GI
29. inc. motility (cramps & diarrhea). Involuntary defecation
Tacrine 3
0. Acetylcholine esterase (-)r. Txt Alzheimer ‘s
Atropine
31. DOC w/ vagal arrest
Glycoperrolate
32. M-r(-). Antispasmodic. Txt peptic ulcers.
Pirenzepine
33. M-r(-). Antispasmodic. Txt peptic ulcers.
Doxacurium
34. Most potent competitive non-depol NMJ (-)r. No cardiovascular side effects. No Histamine release.
â bungarotoxin
35. Prevent the releasal of Ach from vesicles @ the pre synaptic nerve ending
á bungarotoxin
36. Irreversible N-r (-)r = dec. action potentials
á1 & Eye
37. Contracts radial muscle = mydriasis (pupil dilation)
á1 & Arterioles
38. Constiction: inc.TPR = inc. Diastolic pressure = inc. Afterload
á1 & Venules
39. Constriction: inc. Venous return = inc. Preload
á1 & Sex Function
40. Ejaculation
inc. Diastolic
41. inc. á1 = inc.TPR
dec. Diastolic
42. inc. â2; Direct acting vasodilators; (+)Cholinergics
â1 & Heart
43. (+)chronotropism = inc.HR. 44. (+)inotropism = inc. contractility; inc.SV; inc.CO; inc.O2 consumption. 45. inc. conduction velocity
Phenylephrine
46. á1 (+) Nasal decongestant.
â2(+) Asma Drugs
47. Metaproterenol; Albuterol; Terbutaline; Ritodrine; Salmeterol
Ritodrine/Turbutaline
48. Relaxes myometrium used in pre-mature labor pains
Phentolamine
9. Epi reversal. Blocks á, vasodilation occurs. Pt goes from HyperTN to HypoTN. 50. Txt pheochromocytoma = dec.BP
Terazosin
51. Txt BPH
Yohimbine
52. inc. sympathetic outflow = á2 (-). Txt impotence.
Cardioselective NMJ
53. Pancuronium = inc.HR due to atropine-like anti muscarinic vagolytic effect & Gallamine (-)r
Ecothiophate
54. Irreversible cholinesterase (-)r.
Pyridostigmine
55. Cholinomimetic that inc.s M & N-r effects. (-) acetylcholinesterase & plasma cholinesterase 56. DOC for the oral Txt of MG