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45 Cards in this Set
- Front
- Back
Epinephrine
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1. á1, á2, â1, â2
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Norepinephrine
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2. á1, á2, â1 (no â2 activity)
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GABA
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3. Causes an inhibitory cell hyperpolarization
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Muscarinic-r
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4. Uses DAG & IP3 as 2nd messengers 5. Parasympathetic control
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Bethanechol
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6. Cholinergic. inc. GI & Bladder motility. Txt atonic bladder post-op
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Pilocarpine
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7. Cholinergic. Pupillary constriciton= miosis. Ciliary constriction= accomodation. 8. Txt acute glaucoma
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Isoflurophate
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9. Organophosphate. Irreversible acetylcholinesterase (-)r
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Pralidoxime
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10. 2PAM. Reverses organophosphate binding to acetylcholinesterase
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Neostigmine
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11. Reversible acetylcholinesterase (-)r 12. Txt Myasthenia Gravis
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Myasthenia Gravis
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13. Anitbodies to Ach-r. inc. g muscular weakness due to Ach s weak postsynaptic effect @ NMJ. Inactivates-r
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Tubocurium
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14. Nondepol. Competitive cholinergic N-r (-)r. 15. Prevents Ach binding but does not activate NMJ 16. inc. Histamine release= dec. BP & inc. bronchospasm
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Trimethaphan
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17. Nonselectively binds N-r of the PS- and SNS
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Pancurium
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18. More potent than tubocurium w/o histamine release
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Succinylcholine
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19. Depol. Non competitive (-)r of muscle action 20. Opens Na Ch.= fasciculations. Closes Na Ch.= paralysis. Continuous infusion.
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á1 & Eye
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21. Mydriasis due to norepinephrine. Prazosin (-).
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M-r & Eye
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22. Miosis due to Ach. Atropine (-).
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Sympathetic
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23. Post ganglionic symapthetic fibers releases norepinephrine
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Parasym.
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24. Post ganglionic parasympathetic fibers release Ach
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M3-r & Eye
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25. Contracts sphincter = miosis. Contracts ciliary = accomodation.
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M2-r & Heart
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26. Negative chronotropy: dec. HR = vagal arrest 27. Negative inotropy: dec. contractility
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M3-r & Lung
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28. Bronchospasm inc.secretions
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M3-r & GI
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29. inc. motility (cramps & diarrhea). Involuntary defecation
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Tacrine 3
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0. Acetylcholine esterase (-)r. Txt Alzheimer s
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Atropine
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31. DOC w/ vagal arrest
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Glycoperrolate
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32. M-r(-). Antispasmodic. Txt peptic ulcers.
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Pirenzepine
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33. M-r(-). Antispasmodic. Txt peptic ulcers.
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Doxacurium
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34. Most potent competitive non-depol NMJ (-)r. No cardiovascular side effects. No Histamine release.
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â bungarotoxin
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35. Prevent the releasal of Ach from vesicles @ the pre synaptic nerve ending
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á bungarotoxin
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36. Irreversible N-r (-)r = dec. action potentials
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á1 & Eye
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37. Contracts radial muscle = mydriasis (pupil dilation)
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á1 & Arterioles
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38. Constiction: inc.TPR = inc. Diastolic pressure = inc. Afterload
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á1 & Venules
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39. Constriction: inc. Venous return = inc. Preload
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á1 & Sex Function
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40. Ejaculation
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inc. Diastolic
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41. inc. á1 = inc.TPR
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dec. Diastolic
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42. inc. â2; Direct acting vasodilators; (+)Cholinergics
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â1 & Heart
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43. (+)chronotropism = inc.HR. 44. (+)inotropism = inc. contractility; inc.SV; inc.CO; inc.O2 consumption. 45. inc. conduction velocity
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Phenylephrine
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46. á1 (+) Nasal decongestant.
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â2(+) Asma Drugs
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47. Metaproterenol; Albuterol; Terbutaline; Ritodrine; Salmeterol
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Ritodrine/Turbutaline
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48. Relaxes myometrium used in pre-mature labor pains
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Phentolamine
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9. Epi reversal. Blocks á, vasodilation occurs. Pt goes from HyperTN to HypoTN. 50. Txt pheochromocytoma = dec.BP
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Terazosin
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51. Txt BPH
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Yohimbine
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52. inc. sympathetic outflow = á2 (-). Txt impotence.
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Cardioselective NMJ
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53. Pancuronium = inc.HR due to atropine-like anti muscarinic vagolytic effect & Gallamine (-)r
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Ecothiophate
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54. Irreversible cholinesterase (-)r.
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Pyridostigmine
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55. Cholinomimetic that inc.s M & N-r effects. (-) acetylcholinesterase & plasma cholinesterase 56. DOC for the oral Txt of MG
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