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109 Cards in this Set

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This direct cholinergic agonist is good for postoperative and neurogenic ileus AND urinary retention
Bethanechol
"Bethan Call me if you want to activate your Bowels and Bladder"
This direct cholinergic agonist is good for:
Glaucoma,
To induce pupillary contraction,
To decrease intraocular pressure
Carbachol
This direct cholinergic agonist is used as a challenge test for dx of asthma?

Which receptors in particular does it stimulate?
Methacholine

M3
This INDIRECT cholinergic agonist can be used for:
Postoperative and neurogenic ileus,
Urinary Retention,
Myasthenia Gravis,
Reversal of Post-op NMJ blockade

1 Unique thing about this drug?
Neostigmine

DOES NOT cross CNS
This drug can be used to Tx Myasthenia Gravis LONG TERM!

This drug does NOT do what?
Pyridostigmine

(My Pyramids will last a LONG time)

Does not penetrate CNS
This Indirect Cholinergic Agonist (ACHesterase Inhib) has very short FX in myasthenia gravis, and TF can be used to Dx Myasthenia gravis?
Edrophonium
This indirect cholinergic agonist (ACHesterase inhib) can be used to tx:
Glaucoma, Atropine Overdose

Another Indirect Cholinergic agonist that ONLY Tx glaucoma?
Physostigmine

Echothiophate
This indirect cholinergic agonist can be used to tx Alzheimer's
Donepezil
Which 2 direct cholinergic agonists are resistant to AChesterase?
Bethanechol;
Pilocarpine
3 Muscarinic (PNS) Antags that cause mydriasis and cycloplegia of the eye?
Atropine,
Homatropine,
Tropicamide
1 Muscarinic Antag that can be used to tx parkinson's dz?
Benztropine

"PARK my BENZ"
Bethanechol
Direct Cholinergic Agonist
"i'll be DIRECT, BETHANy CARbone's PILlow has seen all the METS"
Carbachol
Direct Cholinergic Agonist
"i'll be DIRECT, BETHANy CARbone's PILlow has seen all the METS"
Pilocarpine
Direct Cholinergic Agonist
"i'll be DIRECT, BETHANy CARbone's PILlow has seen all the METS"
Methacholine
Direct Cholinergic Agonist
"i'll be DIRECT, BETHANy CARbone's PILlow has seen all the METS"
All direct cholinergic agonists

Direct Cholinergic Agonist
"i'll be DIRECT, BETHANy CARbone's PILlow has seen all the METS"
Bethanechol
Carbachol
Pilocarpine
Methacholine
Neostigmine
Indirect Cholinergic Agonists
(AChesterase Inhibs)

"INDIRECTLY, NEO PrEferred PEDs"
Pyridostigmine
Indirect Cholinergic Agonists
(AChesterase Inhibs)

"INDIRECTLY, NEO PrEferred PEDs"
Edrophonium
Indirect Cholinergic Agonists
(AChesterase Inhibs)

"INDIRECTLY, NEO PrEferred PEDs"
Physostigmine
Indirect Cholinergic Agonists
(AChesterase Inhibs)

"INDIRECTLY, NEO PrEferred PEDs"
Echothiophate
Indirect Cholinergic Agonists
(AChesterase Inhibs)

"INDIRECTLY, NEO PrEferred PEDs"
Donepezil
Indirect Cholinergic Agonists
(AChesterase Inhibs)

"INDIRECTLY, NEO PrEferred PEDs"
Name the Indirect Cholinergic Agonists
(AChesterase Inhibs)
"INDIRECTLY, NEO PrEferred PEDs"

Neostigmine
Pyridostigmine
Edrophonium
Physostigmine
Echothiophate
Donepezil
Insectisides -->
Organophosphate Poisoning
(ACHesterase Inhibs)-->
what sx?


Antidote?

MOA of Pralidoxine?
DUMBBELSS

Diarrhea
Urination
Miosis
Bronchospasm
Bradycardia
Excitation of skeletal muscle & CNS
Lacrimation
Sweating
Salivation

Atropine + Pralidoxine

Increases amt ACHesterase
Atropine
Muscarinic (PNS) Antag

EYE
Homatropine
Muscarinic (PNS) Antag

EYE
Tropicamide
Muscarinic (PNS) Antag

EYE
Benztropine
Muscarinic (PNS) Antag

CNS
Scopolamine
Muscarinic (PNS) Antag

CNS
Ipratroprium
Muscarinic (PNS) Antag

Resp
Oxybutynin
Muscarinic (PNS) Antag

GU
Glycopyrrolate
GU
Methscopoloamine
Muscarinic (PNS) Antag

GI
Pirenzepine
Muscarinic (PNS) Antag

GI
Propantheline
Muscarinic (PNS) Antag

GI
Too much atropine -->
Too much antag of PNS -->
Too much SNS -->
What sx?
Hot as a hare- hyperthermia
Dry as a bone- dry mouth, urinary ret
Red as a beet- flushing
Blind as a bat- cycloplegia
Mad as a hatter- delirium
11 Direct Adrenregic Agonists
"ENI Doctors Doing Phree directing and acting. the MAST seems Right"

Epi
NE
Isoproterenol
Dopamine
Dobutamine
Phenylephrine
Metaproterenol
Albuterol
Salmeterol
Terbutaline
Epi
Direct Adrenergic Ag

a1, a2, b1, b2
NE
Direct Adrenergic Ag

a1, a2, b1
Isoproterenol
Direct Adrenergic Ag

b1, b2
Dopamine
Direct Adrenergic Ag

a1 (HD), a2 (HD), b1 (MD), b2 (MD), D1 (LD)
Dobutamine
Direct Adrenergic Ag
a1, a2, MOSTLY b1, b2
Phenylephrine
Direct Adrenergic Ag

a1, a2
Metaproterenol
Direct Adrenergic Ag

b1, b2
Albuterol
Direct Adrenergic Ag


b1, b2
Salmeterol
Direct Adrenergic Ag


b1, b2
Terbutaline
Direct Adrenergic Ag


b1, b2
Ritrodine
Direct Adrenergic Ag


b2
3 Indirect adrenergic ags
"otm: i can ACE indirect"

Amphetamine
Ephedrine
Cocaine
Amphetamine
Indirect adrenergic ag

Release stored catecholamines
Name 2 Sympathoplegics (Inhib SNS)
& how they work
Clonidine
a-methyldopa

a2 agonist
Clonidine
Sympathoplegic a2 agonist
a-methyldopa
Sympathoplegic a2 agonist
Phenoxybenzamine
Irreversible non-selective alpha receptor blocker
Phentolamine
Reversible non-selective alpha receptor blocker
2 non-selective alpha receptor blockers
Phenoxybenzamine (irreversible)
Phentolamine (Reversible)
Three a1 selective alpha receptor blockers?
Prazosin
Terazosin
Doxazosin
Prazosin
a1 selective alpha receptor blocker
Terazosin
a1 selective alpha receptor blocker
Doxazosin
a1 selective alpha receptor blocker
Mirtazapine
a2 receptor blocker
5 b1 selective receptor blockers?
A BEAM of beta-1 blockers

Acebutolol
Betaxolol
Esmolol
Atenolol
Metoprolol
Acebutolol
b1 receptor blocker
Betaxolol
b1 receptor blocker
Esmolol
b1 receptor blocker
Atenolol
b1 receptor blocker
Metoprolol
b1 receptor blocker
4 Non-selective beta blockers?
Please Try NOT being Picky

Propranolol
Timolol
Nadolol
Pindolol
Propranolol
Non-selective beta blocker
Timolol
Non-selective beta blocker
Nadolol
Non-selective beta blocker
Pindolol
Non-selective beta blocker
2 Non-selective vasodilatory alpha & beta receptor blockers?
Carvedilol
Labetalol
Carvedilol
Non-selective vasodilatory alpha & beta receptor blocker
Labetalol
Non-selective vasodilatory alpha & beta receptor blocker
2 Partial beta blockers?
PAPA

Pindolol
Acebutolol
Pindolol
Partial beta blockers
Acebutolol
Partial beta blockers
ANS Pharm
ANS Pharm
This direct cholinergic agonist is a potent stimulator of sweat, tears and saliva?
Pilocarpine
"You cry drool and sweat on your PILow"
1 Muscarinic Antag that can be used for motion sickness?
Scopolamine

(Scallop Fishing Boat)
1 Muscarinic Antag that can be used for Asthma & COPD?
Ipratroprium

"I PRAY i can breathe soon)
2 Muscarinic Antags that will reduce bladder spasm and urgency in mild cystitis?
Oxybutynin
Glycopyrrolate

"if you get OXY clean Glenn says you'll have so much sex that you'll get a GU infxn"
3 Muscarinic Antags that can be used for peptic ulcer tx?
Methscopolamine,
Pirenzepine,
Propantheline
What is the major drug for organophosphate poisoning and how does it work?


What is it given with?
Pralidoxime

Regenerates ACHesterase

Atropine
Atropine is a muscarinic antag that does not only produce mydriasis and cycloplegia, but also can tx what heart cond'n?
Bradycardia
(Think of your ACLS!)
What is the FX of Atropine on:

1) Eye:

2) Airway:

3) Stomach:

4) Gut:

5) Bladder:
1) Mydriasis, Cycloplegia

2) Dec secretions

3) Dec acid secretion

4) Dec motility

5) Dec Urgency in cystitis
Atropine OD --> block of PNS -->
Too much SNS --> what?
Hot as a hare,
Dry as a bone,
Red as a beet,
Blind as a bat,
Mad as a hatter

Hyperthermia (no sweating!)
Urinary retention, dry mouth
Flushing
Cycloplegia, Mydriasis
Delirium
Atropine can be used to block too much PNS. Too much PNS --> what sx?
DUMBBELSS

Diarrhea
Urination
Miosis
Bronchospasm
Bradycardia
Excitation of Sk. Muscle and CNS
Lacrimation
Sweating
Salivation
Which direct acting adrenergic agonist can be used for:
Anaphylaxis,
Glaucoma (Open Angle),
Asthma,
HTN
Epi
Which direct adrenergic agonist can be used for HYPO-TN but will cause dec renal perfusion?
NE
Which direct adrenergic agonist will cause AV block?
Isoproterenol
Which adrenergic agonist will tx:
shock --> dec renal perfusion,
heart failure bc of of its positive inotropic and chronotropic FX,
and is D1> beta > alpha
Dopamine
Which direct adrenergic agonist can be used to tx Heart failure

AND

can be used for cardiac stress testing

AND

has inotropic but NOT chronotropic FX
Dobutamine
Which direct adrenergic agonist is used for nasal decongestion (a1),
and causes vasoconstriction and mydriasis?
Phenylephrine
Which 2 direct adrenergic agonists can be use to tx acute asthma?
Metaproterenol
Albuterol
Which direct adrenergic agonist can be used to tx long term asthma?
Salmeterol
Which direct adrenergic agonist will reduce premature uterine contractions
Ritrodine
What are 3 indirect adrenergic agonists?
Amphetamine
Ephedrine
Cocaine

"OTM: i can ACE INDIRECT"
Which indirect adrenergic agonist can be used to tx Narcolepsy, Obesity, ADD?

MOA?
Amphetamine

Releases stored catecholamines
Which indirect adrenergic agonist can be used to tx Nasal congestion, urinary incontinence and HYPO-TN?

MOA?
Ephedrine

Release stored catecholamines
Which indirect adrenergic agonist can cause vasoconstriction AND TF act as a local anesthetic?

MOA?
Cocaine

Dopamine reuptake inhibitor
What are 2 Sympathoplegic Rx that inhibit the SNS?

MOA?

CU?
Clonidine & a-methyldopa

Centrally acting alpha-agonists

HTN, esp w/ renal dz bc
Which irreversible, non-selective alpha receptor blocker can be used to tx pheochromocytoma?

2 AE?
Phenoxybenzamine

Orthostatic HYPO-TN & Reflex Tachy
Which reversible, non-selective alpha receptor blocker can be used for pts on MAOIs who eat too much tyramine-containing foods?
Phentolamine
Which 3 alpha-1 selective receptor blockers and be used to tx:
HTN,
Urinary retention in BPH

3 AEs of these 3 drugs?
Prazosin, Terazosin, Doxazosin

1st DOSE ORTHOSTATIC HYPO-TN,
dizziness,
HA
MOA of mirtazapine (alpha-2 selective receptor blocker)?

3 AEs?
Mirtazapine

Sedation
Inc Serum Cholesterol
Inc Appetite
6 CU of the beta-blockers?

"HAM SandwiCh!? Gross!
HTN
Angina Pectoris
MI
SVT (Propranolol, Esmolol)
CHF
Glaucoma
5 AEs of beta-blockers?
Impotence,
Exacerbation of asthma,
Cautious use in Diabetics,
Adverse CV FX (brady, av block, CHF),
Adverse CNS FX (Sedation, Sleep alteration)