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10 Cards in this Set
- Front
- Back
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What is the bioavailability of IV vs Oral/Rectal?
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IV - 100%
Oral/Rectal - <100% |
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What is the first pass effect?
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How much drug is absorbed on first pass metabolism through the gut and liver
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What are the characteristics of oral administration?
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Easiest, but exposes drug to intestine/liver metabolism, which may inc first pass effect, CAN CAUSE EMESIS
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What are the characteristics of Parenteral admistration (IV, IM, SubQ, Intraarterial / Intrathecal, Inhalation)?
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IV - preferred for emergency, MOST DIRECT ROUTE
IM - drugs in aqueous solution SubQ - only give small doses, slow metabolism, use for large pellets IA/IT - used to put high concentrations in a specific organ Inhalation - gaseous anesthetics, rapid absorption |
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What are the characteristics of Topical administration (Transdermal, buccal/sublingual, rectal)?
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Transdermal - rapid + controlled penetration through the skin
B/S - self administered drugs that have high first pass metabolism, as this uses systemic veins, not portal circulation Rectal - unconscious pt's or when oral route induces emesis, drugs do not pass through liver |
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What is stored in fat?
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Lipid soluble drugs
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What is stored in tissue (skeletal mm)?
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Man drugs
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What is stored in bone?
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Tetracyclines
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What is stored in plasma proteins?
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Drugs that have a high degree of plasma protein binding, accumulate in plasma water
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What are the 5 sites of drug exclusion?
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CSF, ocular fluid, endolymph fluid, fetal fluid, pleural fluid
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