Pharm 2 Test

Front 1

Hypotension, pressor agent α / β1 β3 (β2) neuronal, non-circulating, I:MAOI, TCA

Back 1

Norepinephrine

Front 2

Allergic reactions, shock, CPR α / β1 β2 (β3) adrenal medulla, circulate; I: maoi,TCA

Back 2

Epinephrine

Front 3

Renal vasodilatation during shock α1 / β1 / D, precursor to NE, I: MAOI

Back 3

Dopamine

Front 4

Asthma, cardiac stimulant β, synthetic, not endogenous; BP(↓, --) HR↑

Back 4

Isoproterenol

Front 5

Nasal decongestant, hypotension, Not commonly used for hypotension;S: CV, reflex bradycardia

Back 5

Phenylephrine

Front 6

Hypertension, Opioid withdrawal, α2, ↓ cns sympathetic outflow, inhibit NE release,rebound HT; S: dry mouth, sedation, impotence.α-methyl-dopa is metabolized to α-methyl-NE (α2-agonist, positive Coombs test)

Back 6

Clonidine

Front 7

CHF, cardiac stimulant β1, iv infusion, tolerance, desensitization

Back 7

Dobutamine

Front 8

CHF, cardiac stimulant β1, iv infusion, tolerance, desensitization, Albuterol (Proventil, Ventolin) Asthma - bronchodilator, β2--selective, oral 1-2 hrs onset

Back 8

Dobutamine

Front 9

Premature labor, β2--selective

Back 9

Ritodrine

Front 10

Parkinson’s disease precursor to DA, cross to CNS

Back 10

L-Dopa

Front 11

Nasal decongestant, red eyes α /β, also indirect to release NE; I: AOI, TCA

Back 11

Ephedrine

Front 12

Narcolepsy, hyperactivity, [obesity], Displaces NE, CNS stimulant, requires uptake1,can cause tolerance, tachyphylaxus

Back 12

Amphetamine

Front 13

Hyperactivity disorder (ADHD), Displaces NE, CNS stimulant, requires uptake1,can cause tolerance, tachyphylaxus

Back 13

Methylphenidate

Front 14

None, [high] in red wine & cheese interaction with MAO inhibitors,

Back 14

Tyramine

Front 15

Pheochromocytoma, acute, chronic HT α1, irreversible, S: PHT

Back 15

Phenoxybenzamine

Front 16

Pheochromocytoma, acute HT α, competitive, S: PHT, reflex tachycardia

Back 16

Phentolamine

Front 17

Hypertension (HT), benign prostrate hypertrophy α1, competitive; no reflex tachycardia S: 1st pass effect, PHT, nausea, drowsiness

Back 17

Prazosin

Front 18

Hypertension, angina, arrhythmias, tremor,migraine, hyperthyroidism (propranolol),panic stress β, non-selective, LA-action, no ISA; Useful group, CI:heart failure (unstable CHF, depression, bradycardia or brochospasm), asthma, diabetes, Raynaud D

Back 18

Propranolol

Front 19

Hypertension, angina, arrhythmias β, LA-action, ISA, angina commonly

Back 19

Pindolol

Front 20

Glaucoma, decrease secretion; (HT) β, no LA-action, no ISA, glaucoma commonly

Back 20

Timolol

Front 21

Hypertension, angina, arrhythmias, CHF β1, LA-action, no ISA, arrhythmia commonly

Back 21

Metoprolol

Front 22

Hypertension, angina β1, no LA-action, no ISA

Back 22

Atenolol

Front 23

Arrhythmias, [angina] β1, no LA-action, no ISA, very short acting

Back 23

Esmolol

Front 24

Hypertensive crisis, hypertension, CHF β & α -blocker, some β-agonist action

Back 24

Labetalol

Front 25

Hypertensive crisis, hypertension, CHF β & α -blocker

Back 25

Carvedilol

Front 26

inhibit neuronal uptake, cross CNS; I: CA's, amph.

Back 26

Cocaine

Front 27

Attention deficient hyperactivity (ADHD) inhibit NE neuronal uptake

Back 27

Atomoxetine

Front 28

No major use, minor ocular procedures for brief miosis; muscarine found in certain mushrooms M / N, short acting (AchE); T/S: All M-agonists: salivation, lacrimation, urination, diarrhea, emesis, (slude), miosis, cyclopleg, bronchoconstriction, ↓HR

Back 28

Acetylcholine

Front 29

Atonic gut, urinary retention M, resistant to AchE

Back 29

Bethanechol

Front 30

Acute & chronic glaucoma M, resistant to AchE; alkaloid, increase outflow

Back 30

Pilocarpine

Front 31

Glaucoma, if pilocarpine ineffective M / some N, resistant to AchE

Back 31

Carbachol

Front 32

Ocular procedures M, resistant to AchE

Back 32

Methacholine

Front 33

Diagnostic for myasthenia gravis competitive, short-acting (5-10min)

Back 33

Edrophonium

Front 34

Myasthenia gravis, reverse nmj block reversible, no CNS, some direct agonist action

Back 34

Neostigmine

Front 35

Myasthenia gravis AchE inhibitors occupy AchE and prevent Ach degradation, T/S: same as for high Ach

Back 35

Pyridostigmine

Front 36

Reverse atropine toxicity; glaucoma reversible, CNS action

Back 36

Physostigmine

Front 37

Organophosphate, Glaucoma (also cause miosis, cycloplegia)

Back 37

DFP (Isoflurophate)

Front 38

Glaucoma (also cause miosis, cycloplegia

Back 38

Echothiophate

Front 39

Insecticides (Inactive, converted to active, form in body, parathion more toxic)

Back 39

Malathion, Parathion

Front 40

(nerve gases

Back 40

Vx, sarin, soman

Front 41

↓GI activity, ↓secretions, relax lung, mydriasis (pupil dilation), cyclopegia (loss of accommodation), competitive M-antagonists, pirenzepine (M1- selective); T: mad as a hatter (unresponsive), red as a beet (erythematous, direct vasodilation), blind as a bat (cycloplegia), dry as a bone (↓secretions), hot as hell (thermoregulation); Reverse toxic effects with AchE inhibitors eg. physostigmine or neostigmine. Horner’s S.: miosis, sagging eyelid. Damage to sympathic innervation, no cocaine response, pre- (Tyr response) or post-ganglionic (no Tyr response)

Back 41

Cholinoceptor Antagonists

Front 42

Reverse AChE inhibition; GI-disorders, ocular (iritis), vagolysis

Back 42

Atropine

Front 43

Asthma – bronchodilator

Back 43

Ipratropium

Front 44

Parkinson's disease, esp. drug induced

Back 44

Benztropine

Front 45

Motion sickness, diarrhea, ↓secretions

Back 45

Scopolamine

Front 46

GI-disorders ie. mild diarrhea, [peptic ulcer

Back 46

Propantheline

Front 47

Ocular examination

Back 47

Cyclopentolate

Front 48

inhibit choline uptake (rate limiting step)

Back 48

Hemicholinium

Front 49

↓Ach release (prevent vesicle fusion), 3-4 mths

Back 49

Botulinus toxin

Front 50

Regenerate AchE need to use before ‘aging’ occurs

Back 50

Pralidoxime, (2-PAM)

Front 51

Insecticide, cigarettes N-agonist, (blocker) T: convulsions, vomiting, CV

Back 51

Nicotine,

Front 52

↓ BP during surgery, Nn-antagonists, (competitive), not taken orally

Back 52

Trimethapan

Front 53

↓ BP during surgery, Nn-antagonists, (competitive), taken orally

Back 53

Mecamylamine

Front 54

NMJ paralysis, depolarizing block, short acting due to plasma AchE; fasciculations, Atypical AchE, Malignant H, Hyperkalemia (delayed)

Back 54

Succinylcholine

Front 55

NMJ paralysis, competitive blockers, Small/fast nerves first (face, hands), then trunk, respiratory muscles last. Flaccid paralysis. Can reverse block with AchE inhibitors -Nm, some histamine release & ganglia block

Back 55

Tubocurarine

Front 56

NMJ paralysis, competitive blockers, Small/fast nerves first (face, hands), then trunk, respiratory muscles last. Flaccid paralysis. Can reverse block with AchE inhibitors -short acting 10-20 min, slight histamine release

Back 56

Mivacurium

Front 57

NMJ paralysis, competitive blockers, Small/fast nerves first (face, hands), then trunk, respiratory muscles last. Flaccid paralysis. Can reverse block with AchE inhibitors

Back 57

Rocuronium,

Front 58

Prostaglandin, Glaucoma, ↑ outflow. S: brown pupil, red eyes (inflammation)

Back 58

Latanoprost (PGF2α analogue) (Xalatan