Phar 3100 Exam 1

Front 1

Selegiline

Back 1

Targets Parkinson's disease. Inhibits DA metabolism. Can intteract with SSRIs and cause hypertensive crisis.

Front 2

Apomorphine

Back 2

Emergency rescue drug for "off state" in Parkinson\s patients.

Front 3

Thioridazine

Back 3

Typical antipsychotic. Highly cholinergic. Highly sedative, but low rate of drug-induced Parkinsonism.

Front 4

Domperidone

Back 4

Anti-nausea. Originally antipsychotic.

Front 5

Chloropromazine

Back 5

Typical antipsychotic. Awful side effects.

Front 6

Haloperidol

Back 6

Typical antipsychotic. Low anticholinergic properties. Lightly sedative, strong motor effects.

Front 7

Risperidone

Back 7

Atypical antipsychotic. Also strong D2 antagonist. Less motor side effects than typical antipsychotics, but may elevate anxiety and depression.

Front 8

Clozapine

Back 8

Atypical antipsychotic. Also weak D2 antagonist. No motor side effects, helpful with tardive dyskinesia. Can cause agranulocytosis.

Front 9

Olanzapine

Back 9

Atypical antpsychotic. Also weak D2 antagonist. No motor side effectts or agranulocytosis,

Front 10

Aripiprazole

Back 10

Antipsychotic. Mild presynaptic D2 agonist and postsynaptic D2 antagonist. No motor side effects, potentially does not cause weight gain like other antipsychotics.

Front 11

Phenobarbital

Back 11

Antiepileptic (all types). Low dose barbituate, can be overly sedativee and mess with hepatic metabolism.

Front 12

Clonazepam

Back 12

Antiepileptic (all types). Benzodiazepine, less sedative than barbituates.

Front 13

Lorazepam

Back 13

Antiepileptic (status epilepticus only). Benzodiazepine, less sedative than barbituates.

Front 14

Carbamazepine

Back 14

Antiepileptic and bipolar disorder treatment. Blocks Na+ channels. Can cause ataxia, vertigo, and nystagmus.

Front 15

Ethosuximide

Back 15

Antiepileptic (absence seizures only). Blocks Ca2+ channels. Can cause gastrointestinal distress.

Front 16

Cannabidiol ("Charlotte's Web")

Back 16

Antiepileptic. Strain of mariuana with low THC content.

Front 17

Clomipramine

Back 17

Tricyclic antidepressant. NE reuptake inhibitor. Causes SLUDs and orthostatic hypotension. Also treats OCD and trichotillomania.

Front 18

Phenelzine

Back 18

MAO inhibitor antidepressant. Blocks NE, DA, and 5-HT metabolism. Interacts negatively with many foods.

Front 19

Fluoxetine and Sertraline

Back 19

SSRI antidepressants. Safest drugs for depression.

Front 20

Venlafaxine

Back 20

SNRI antidepressant. Inhibits 5-HT and NE metabolism. Must take 2-3 times per day.

Front 21

Bupropion

Back 21

Atypical antidepressant. Blocks NE and (potentially) DAreuptake, and is a noncompetitive nAchR antaagonist - can assist in recovery from nicotine addiction. Can cause nervousness and insomnia.

Front 22

Asprin and Naproxen

Back 22

Alzheimer's prophylactics NSAIDs.

Front 23

Lovastatin

Back 23

Alzheimer's prophylactic, statin. Decreaeses hypercholesterolemia.

Front 24

Donepezil

Back 24

Targets Alzheimer's disease. Reversible cholinesterase inhibitor (cholnomimetic). Cholinergic side effects, hepatotoxic interactions. Take 1 per day.

Front 25

Rivastigmine

Back 25

Targts Alaheimer's disease. Reversible cholinesterse inhibitor (cholinomimetic). No hepatotoxic interactions, but must take 2 per day.

Front 26

Memantine

Back 26

Targets Alzheimer's disease. Reversible NMDAr antagonist. Removed by large Glu pulses, allowing learning. Works well in combination with reversible cholinesterase inhibitors.

Front 27

Levadopa (L-Dopa)

Back 27

Targets Parkinson's disease. DA precursor, but causes nausea due to lack of absorption into brain. Can cause psychosis.

Front 28

Sinemet

Back 28

Targets Parkinson's disease. L-Dopa with Carbidopa. Does not cause nausea, may cause psychosis.

Front 29

Entacapone

Back 29

Targets Parkinson's disease. Peripheral COMT inhibitor, prevents eliination of L-Dopa, increasing half life and bioavailability of Sinemet. Particularly useful for "on-off" effects.

Front 30

Scopolamine

Back 30

Targets vertigo. Originally anticholinergic Parkinson's drug.

Front 31

Benzatropine

Back 31

Targets Parkinson's disease. Anticholinergic. Low TI, SLUDs.

Front 32

Bromocriptine

Back 32

Targets Parkinson's disease. D2 agonist, early monotherapy or late adunct therapy. May cause dyskinesia or hallycinations.

Front 33

Amantidine

Back 33

Targets Parkinson's disease. Stimulates DA relase, blocks Glu release. Early monotherapy or late adunct therapy.

Front 34

Lithium

Back 34

Targets bipolar disorder/mania. Mechanism unknown, most likely alters 5-HT and NE transission.

Front 35

Flumazenil

Back 35

Reverses benzodiazepine effects. Causes increased anxiety.

Front 36

Midazolam and Triazolam

Back 36

Sedatives. Short-acting benzodiazepines, few side effects.

Front 37

Secobarbital

Back 37

Sedative. Mid-to long-lasting barbituate, lethal in high doses.

Front 38

Diphenhydramine

Back 38

Sedative. Antihistamine, anticholinergic. Very safe.

Front 39

Busiprone

Back 39

Anxiolyti. 5-HT1Ar agonist. Takes weeks to work, but no side effects.

Front 40

Zolpidem ("Z-Drugs")

Back 40

Non-anxiolytic sedative. Acts on site of benzodiazepines. Can cause mild psychological dependence.

Front 41

Melatonin

Back 41

Sedative, mild hypnotic. Not always pure when sold as dietary supplement, but useful against jet-lag.

Front 42

Thiopental

Back 42

Anesthetic. Short-acting barbitate, IV inection. Can suppress respiration and heartbeat.

Front 43

Ketamine

Back 43

Anesthetic. NMDAr modulator, similar to PCP. Causes dissociative anesthesia.

Front 44

Nitrous oxide

Back 44

Anesthetic. Inhaant. Analgesic, useful for potentiation of other analgesics. Can OD.

Front 45

Halothane

Back 45

Inhalant anesthetic. Causes hangover effects, risk of liver damage.

Front 46

Isoflurane

Back 46

Inhalant anesthetic. Safer than others, suppresses respiration and heartbear less.