Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
13 Cards in this Set
- Front
- Back
|
What type of bacteria are most penicillins used for? (With the exception of broad spectrums) |
Gram +ve bacteria and Nisseria gonorrhea |
|
|
What is the half life of penicillin G? |
4-6 hours |
|
|
What are the two penicillins G? |
Benzathine and procaine penicillins |
|
|
What is the half life of Procaine penicillin G? |
12-24 hrs |
|
|
What is the half of benzathine penicillin G? |
3 weeks |
|
|
What is the route of administration of penicillin G? |
Intramuscular (with the use of topical anesthetic lidocaine) bc of strong hydrolyzation with HCL |
|
|
What property do anti-staphylococcal Penicillins have? |
They are narrow spectrum penicillins that are resistant to beta lactamase |
|
|
Differentiate between ampicillin and amoxicillin |
They are both broad spectrum penicillins combined with amino acid. Amoxicillin: Duration: 8 hrs Absorption: quickly absorbed (lipid soluble) Not affected by food
Ampicillin: 4 hrs Slow absorption May be used for ttt of clostridium difficile infection Taken 2 hrs before and after eating |
|
|
What are the disadvantages of penicillin? |
Resistance (Penicillinease or B-lactamase) Short action Narrow +ve only Penicillin G strongly hydrolyzed by HCL |
|
|
What is the significant clinical use of penicillin? |
Natural penicillins are drug of choice in Gas Gangrene |
|
|
What are the prophylactic uses of penicillins |
Rheumatic fever recurrence Surgical procedures in pts with valvular disease Dental extraction Tonsillectomy Intestinal operation and bacteremia |
|
|
What are the side effects of penicillins? |
Cross allergic reactions with B-lactams Candidiasis GIT disturbance, pseudomembranous colitis Nephritis (methicillin) Decreased blood coagulation with high doses of piperacillin and nafcillin |
|
|
What is the DOC for C.difficile infection ttt? |
1st DOC: Metronidazole 2nd DOC: Vancomycin |
