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35 Cards in this Set

  • Front
  • Back
Clinical signs and symptoms of anaphylaxis usually occur within _ time of exposure to offending agent.
30 minutes
Dz that is an IgE mediated inflammatory response in the nasal mucosa to inhaled antigen?
Allergic Rhinitis
2 most common causes of perennial rhinitis
dust mites, animal dander
Most effective method to diagnose allergic rhinitis? What must be stopped 4-7 days prior to testing?
skin test with purified antigen. Must stop antihistamines!
Most effective class of drugs for controlling rhinitis symptoms? Other agents (4)?
intranasal steroids most effective, than antihistamines, intranasal cromolyn Na, decongestants (beware rebound), immunotherapy
Chronic inflammatory skin condition characterized by dry skin, pruritus and lichenification
Atopic Dermatitis (eczema)
T/F - Eczema typically begins in early infancy
Describe the Acute and Chronic Changes of Eczema
Acute - erythema, weeping/crusting, often 2ndry infection;
Chronic - lichenification, pigment changes (hyper > hypo)
Diagnostic Criteria of Atopic Dermatitis
3/4 Major Criteria
1. pruritus, 2. FH, 3. typical morphology & distrib
4. relapsing/chronic drmatitis
T/F - Exclusive breastfeeding for 6 months may decrease food allergies and eczema in an infant
The Test for Food Allergies?
Radioallergosorbent Test (serum IgE for food antigens)
Definitive Test for Food hypersensitivity
Double blind placebo controlled food challenge
What is circumscribed, raised, evanexcent areas of edema that are almost always pruritic?
Urticaria (hives)
2 groups at specific risk for latex allergy
health care worksers and myelomingocele
Time frame btw Acute and Chronic Urticaria
> 6 months = chronic
Selective IgA deficiency is characterized by serum IgA? Treatment?
serum < 7 mg/dL, IgA cannot be replaced so management is ia treating infections and other complications
Most common immune deficiency
IgA deficiency
How can you determine diminished antibody funciton?
measure titers in response to childhood immunizations
What is Common Variable Immunodeficiency? Treatment?
heterogenous group of disorders of hypogammaglobulinemia;
Treatment - Monthly IVIG replacement, Aggressive ABX management, chronic diarrhea management
Increased susceptibility to infection with the first few months of life with common and opportunistic infection is common with?
Management of SCID (4)?
1. irradiated blood products
2. Monthly IVIG replaced
3. PCP Prophylaxis (TM-SMX)
4. BMT can be curative
Describe Ataxia Telanctasia (5)? Should Avoid What?
1. Auto Recessive Chr. 11
2. Combined ImmDef
3. Cerebellar Ataxia (wheelchair by adolesc)
4. Oculocut. Telangiectasisa
5. Predisposition to Malignancy so Avoid Ionizing Radiation
Describe the features of Digeorge Syndrome?
Cardiac defects, abnormal facies, thymic hypoplasia, cleft palate, hypocalcemia, microdelection on 22q11
Describe the features of Wiskott-Aldrich Syndrome (4)?
X linked disorder of Combined ImDef, Eczema, and Thrombocytopenia
What organisms are Wiskott-Aldrich patients susceptible to specifically?
encapsulated organisms
Diagnostic Tests in W-A syndrome(2)? Therapy?
CBC (thrombocytop), IgM decreased; Therapy of choice is HLA-matched BMT with IVIG and splenectomy + prophylactic abx
X-Linked Bruton's Agammaglobulinemia is characterized by ? Treatment?
severe B cell deficiency with normal T cells; Treatment IVIG
Chronic Granulomatous Disease is predominately inherited by ?
Diagnositic Test for CGD (2).
nitroblue tetrazolium or flow cytommetric assay
Treatment of CGD (5)
1. drain abscesses
2. prophy. TM-SMX
3. prophy. itraconazole
4. IFN-gamma
5. BMT is curative
AutoRec condition characterized by decreased neutrophil chemotaxis, cyclic neutropenia, and pancreatic exocrine insuf. Patient often presents recurrent soft tissue infections, chronic diarrhea, and FTT.
Schwachman-Diamond Syndrome
Syndrome of variable neutropenia and thrombocytopenia with gian lysosomal granules in PMNs. Also with partial oculocutaneous albinism.
Chediak-Higashi Syndrome
Defiecienices of early components of complement are associated with _.
A/I dz
Defiecienices of late components of complement are associated with _.
meningococcal and gonococcal infections
T/F - A total serum hemolytic CH50 complement indicates fully functional pathway.