Pediatrics Brs Chapter 15

Front 1

Clinical signs and symptoms of anaphylaxis usually occur within _ time of exposure to offending agent.

Back 1

30 minutes

Front 2

Dz that is an IgE mediated inflammatory response in the nasal mucosa to inhaled antigen?

Back 2

Allergic Rhinitis

Front 3

2 most common causes of perennial rhinitis

Back 3

dust mites, animal dander

Front 4

Most effective method to diagnose allergic rhinitis? What must be stopped 4-7 days prior to testing?

Back 4

skin test with purified antigen. Must stop antihistamines!

Front 5

Most effective class of drugs for controlling rhinitis symptoms? Other agents (4)?

Back 5

intranasal steroids most effective, than antihistamines, intranasal cromolyn Na, decongestants (beware rebound), immunotherapy

Front 6

Chronic inflammatory skin condition characterized by dry skin, pruritus and lichenification

Back 6

Atopic Dermatitis (eczema)

Front 7

T/F - Eczema typically begins in early infancy

Back 7

True

Front 8

Describe the Acute and Chronic Changes of Eczema

Back 8

Acute - erythema, weeping/crusting, often 2ndry infection;
Chronic - lichenification, pigment changes (hyper > hypo)

Front 9

Diagnostic Criteria of Atopic Dermatitis

Back 9

3/4 Major Criteria
1. pruritus, 2. FH, 3. typical morphology & distrib
4. relapsing/chronic drmatitis

Front 10

T/F - Exclusive breastfeeding for 6 months may decrease food allergies and eczema in an infant

Back 10

True

Front 11

The Test for Food Allergies?

Back 11

Radioallergosorbent Test (serum IgE for food antigens)

Front 12

Definitive Test for Food hypersensitivity

Back 12

Double blind placebo controlled food challenge

Front 13

What is circumscribed, raised, evanexcent areas of edema that are almost always pruritic?

Back 13

Urticaria (hives)

Front 14

2 groups at specific risk for latex allergy

Back 14

health care worksers and myelomingocele

Front 15

Time frame btw Acute and Chronic Urticaria

Back 15

> 6 months = chronic

Front 16

Selective IgA deficiency is characterized by serum IgA? Treatment?

Back 16

serum < 7 mg/dL, IgA cannot be replaced so management is ia treating infections and other complications

Front 17

Most common immune deficiency

Back 17

IgA deficiency

Front 18

How can you determine diminished antibody funciton?

Back 18

measure titers in response to childhood immunizations

Front 19

What is Common Variable Immunodeficiency? Treatment?

Back 19

heterogenous group of disorders of hypogammaglobulinemia;
Treatment - Monthly IVIG replacement, Aggressive ABX management, chronic diarrhea management

Front 20

Increased susceptibility to infection with the first few months of life with common and opportunistic infection is common with?

Back 20

SCID

Front 21

Management of SCID (4)?

Back 21

1. irradiated blood products
2. Monthly IVIG replaced
3. PCP Prophylaxis (TM-SMX)
4. BMT can be curative

Front 22

Describe Ataxia Telanctasia (5)? Should Avoid What?

Back 22

1. Auto Recessive Chr. 11
2. Combined ImmDef
3. Cerebellar Ataxia (wheelchair by adolesc)
4. Oculocut. Telangiectasisa
5. Predisposition to Malignancy so Avoid Ionizing Radiation

Front 23

Describe the features of Digeorge Syndrome?

Back 23

CATCH-22;
Cardiac defects, abnormal facies, thymic hypoplasia, cleft palate, hypocalcemia, microdelection on 22q11

Front 24

Describe the features of Wiskott-Aldrich Syndrome (4)?

Back 24

X linked disorder of Combined ImDef, Eczema, and Thrombocytopenia

Front 25

What organisms are Wiskott-Aldrich patients susceptible to specifically?

Back 25

encapsulated organisms

Front 26

Diagnostic Tests in W-A syndrome(2)? Therapy?

Back 26

CBC (thrombocytop), IgM decreased; Therapy of choice is HLA-matched BMT with IVIG and splenectomy + prophylactic abx

Front 27

X-Linked Bruton's Agammaglobulinemia is characterized by ? Treatment?

Back 27

severe B cell deficiency with normal T cells; Treatment IVIG

Front 28

Chronic Granulomatous Disease is predominately inherited by ?

Back 28

X-linked

Front 29

Diagnositic Test for CGD (2).

Back 29

nitroblue tetrazolium or flow cytommetric assay

Front 30

Treatment of CGD (5)

Back 30

1. drain abscesses
2. prophy. TM-SMX
3. prophy. itraconazole
4. IFN-gamma
5. BMT is curative

Front 31

AutoRec condition characterized by decreased neutrophil chemotaxis, cyclic neutropenia, and pancreatic exocrine insuf. Patient often presents recurrent soft tissue infections, chronic diarrhea, and FTT.

Back 31

Schwachman-Diamond Syndrome

Front 32

Syndrome of variable neutropenia and thrombocytopenia with gian lysosomal granules in PMNs. Also with partial oculocutaneous albinism.

Back 32

Chediak-Higashi Syndrome

Front 33

Defiecienices of early components of complement are associated with _.

Back 33

A/I dz

Front 34

Defiecienices of late components of complement are associated with _.

Back 34

meningococcal and gonococcal infections

Front 35

T/F - A total serum hemolytic CH50 complement indicates fully functional pathway.

Back 35

True